Evidence map›Paper›PMID 34083442›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Spatial distribution of LTi-like cells in intestinal mucosa regulates type 3 innate immunity.

Cristiane Sécca, Jennifer K Bando, José L Fachi, Susan Gilfillan, Vincent Peng, Blanda Di Luccia, Marina Cella, Keely G McDonald, Rodney D Newberry, Marco Colonna

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Alterations in mucosa branchedGut microbes · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. ILC3: a case of conflicted identity.Frontiers in immunology · 2023
    Review
  14. Review
  15. Innate Lymphoid Cells and Inflammatory Bowel Disease.Advances in experimental medicine and biology · 2022
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Cristiane SéccaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-4433-8962
Jennifer K BandoDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-1331-7424
José L FachiLaboratory of Immunoinflammation, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil.
Susan GilfillanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-1672-0996
Vincent PengDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Blanda Di LucciaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Marina CellaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-1230-1313
Keely G McDonaldDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Rodney D NewberryDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-4152-5191
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110; mcolonna@wustl.edu.ORCID 0000-0001-5222-4987
Washington University in St. Louis · USStanford University · USUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
Pediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8M
The role of TGFbeta in development and function of salivary gland innate lymphoid cellsR01DE025884 · NIDCR · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, WEISMAN, GARY ANDREW · 2017 to 2021
$3.5M
Plasticity of Innate Lymphoid Cells: Mechanisms and Biological ImpactR01DK124699 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2020 to 2023
$1.4M
Immune Checkpoints for Intestinal Innate Lymphoid CellsR00DK118110 · NIDDK · STANFORD UNIVERSITY · PI BANDO, JENNIFER KAORU · 2021 to 2023
$747k
Immune Checkpoints for Intestinal Innate Lymphoid CellsK99DK118110 · NIDDK · WASHINGTON UNIVERSITY · PI BANDO, JENNIFER KAORU · 2019 to 2020
$182k
Determining the contribution of polyamine biosynthesis to the function of group 3 innate lymphoid cells in the gastrointestinal systemF30DK127540 · NIDDK · WASHINGTON UNIVERSITY · PI PENG, VINCENT · 2020 to 2022
$106k
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS U01 AI095542NIDCR NIH HHS R01 DE025884NIDDK NIH HHS F30 DK127540NIDDK NIH HHS K99 DK118110NIDDK NIH HHS R00 DK118110NIDDK NIH HHS R01 DK124699NIDDK NIH HHS T32 DK077653
6 · The paper itself

Abstract

Lymphoid tissue inducer (LTi)-like cells are tissue resident innate lymphocytes that rapidly secrete cytokines that promote gut epithelial integrity and protect against extracellular bacterial infections.Here, we report that the retention of LTi-like cells in conventional solitary intestinal lymphoid tissue (SILT) is essential for controlling LTi-like cell function and is maintained by expression of the chemokine receptor CXCR5. Deletion of

Indexed as

Immunity, InnateAnimalsGene DeletionInterleukin-17Interleukin-22InterleukinsIntestinal MucosaLymphocytesMiceMice, KnockoutReceptors, CXCR5CXCR5 protein, mouseIl17a protein, mouseInterleukin-17Interleukin-22InterleukinsReceptors, CXCR5CXCR5innate lymphoid cellsintestinelymphoid tissuemucosal immunity

Identifiers

PMID34083442
PMCPMC8201890
OpenAlexW3165215660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.