Evidence map›Paper›PMID 34083427›Full record

Observational studyEmergency medicine journal : EMJ2021

Prognostic accuracy of emergency department triage tools for adults with suspected COVID-19: the PRIEST observational cohort study.

Ben Thomas, Steve Goodacre, Ellen Lee, Laura Sutton, Matthew Bursnall, Amanda Loban, Simon Waterhouse, Richard Simmonds, Katie Biggs, Carl Marincowitz and 13 more

Open access · hybridAbstract readComparative StudyMulticenter StudyObservational Study
In one paragraph

Observational study in Emergency medicine journal : EMJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  18. Evaluation of the utility of NEWS2 during the COVID-19 pandemic.Clinical medicine (London, England) · 2022
    Review
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 1 country.

Ben ThomasScHARR, The University of Sheffield, Sheffield, UK b.d.thomas@sheffield.ac.uk.ORCID http://orcid.org/0000-0002-6659-6930
Steve GoodacreScHARR, The University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0003-0803-8444
Ellen LeeScHARR, The University of Sheffield, Sheffield, UK.
Laura SuttonScHARR, The University of Sheffield, Sheffield, UK.
Matthew BursnallScHARR, The University of Sheffield, Sheffield, UK.
Amanda LobanScHARR, The University of Sheffield, Sheffield, UK.
Simon WaterhouseScHARR, The University of Sheffield, Sheffield, UK.
Richard SimmondsScHARR, The University of Sheffield, Sheffield, UK.
Katie BiggsScHARR, The University of Sheffield, Sheffield, UK.
Carl MarincowitzScHARR, The University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0003-3043-7564
José SchutterScHARR, The University of Sheffield, Sheffield, UK.
Sarah ConnellyScHARR, The University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0001-9963-5628
Elena SheldonScHARR, The University of Sheffield, Sheffield, UK.
Jamie HallScHARR, The University of Sheffield, Sheffield, UK.
Emma YoungScHARR, The University of Sheffield, Sheffield, UK.
Andrew BentleyAcute intensive Care Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
Kirsty ChallenEmergency Department, Lancashire Teaching Hospitals NHS Foundation Trust, Chorley, UK.
Chris FitzsimmonsSheffield Children's Hospital NHS Foundation Trust, Sheffield, UK.
Tim HarrisDepartment of Emergency Medicine, Royal London Hospital, London, UK.
Fiona LeckyScHARR, The University of Sheffield, Sheffield, UK.
Andrew LeeScHARR, The University of Sheffield, Sheffield, UK.
Ian MaconochiePaediatric ED, Imperial College Healthcare NHS Trust, London, UK.
Darren WalterEmergency Department, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.
University of Sheffield · GBManchester University NHS Foundation Trust · GBImperial College Healthcare NHS Trust · GBLancashire Teaching Hospitals NHS Foundation Trust · GBRoyal London Hospital · GBSheffield Children's NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe WHO and National Institute for Health and Care Excellence recommend various triage tools to assist decision-making for patients with suspected COVID-19. We aimed to compare the accuracy of triage tools for predicting severe illness in adults presenting to the ED with suspected COVID-19.

methodsWe undertook a mixed prospective and retrospective observational cohort study in 70 EDs across the UK. We collected data from people attending with suspected COVID-19 and used presenting data to determine the results of assessment with the WHO algorithm, National Early Warning Score version 2 (NEWS2), CURB-65, CRB-65, Pandemic Modified Early Warning Score (PMEWS) and the swine flu adult hospital pathway (SFAHP). We used 30-day outcome data (death or receipt of respiratory, cardiovascular or renal support) to determine prognostic accuracy for adverse outcome.

resultsWe analysed data from 20 891 adults, of whom 4611 (22.1%) died or received organ support (primary outcome), with 2058 (9.9%) receiving organ support and 2553 (12.2%) dying without organ support (secondary outcomes). C-statistics for the primary outcome were: CURB-65 0.75; CRB-65 0.70; PMEWS 0.77; NEWS2 (score) 0.77; NEWS2 (rule) 0.69; SFAHP (6-point rule) 0.70; SFAHP (7-point rule) 0.68; WHO algorithm 0.61. All triage tools showed worse prediction for receipt of organ support and better prediction for death without organ support. At the recommended threshold, PMEWS and the WHO criteria showed good sensitivity (0.97 and 0.95, respectively) at the expense of specificity (0.30 and 0.27, respectively). The NEWS2 score showed similar sensitivity (0.96) and specificity (0.28) when a lower threshold than recommended was used.

conclusionCURB-65, PMEWS and the NEWS2 score provide good but not excellent prediction for adverse outcome in suspected COVID-19, and predicted death without organ support better than receipt of organ support. PMEWS, the WHO criteria and NEWS2 (using a lower threshold than usually recommended) provide good sensitivity at the expense of specificity. TRIAL REGISTRATION NUMBER: ISRCTN56149622.

Indexed as

Emergency Service, HospitalAgedCOVID-19Early Warning ScoreFemaleHumansMaleMiddle AgedPandemicsPneumonia, ViralPredictive Value of TestsPrognosisProspective StudiesRetrospective StudiesSARS-CoV-2Triageclinical assessmentemergency care systemsemergency departmentinfectious diseasestriageviral

Identifiers

PMID34083427
PMCPMC8182747
OpenAlexW3164141330

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.