ArticleHeart (British Cardiac Society)2021
Cumulative burden of clinically significant aortic stenosis in community-dwelling older adults.
Article in Heart (British Cardiac Society), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Structural heart disease screening using artificial intelligence-enabled electrocardiogram and novice handheld cardiac ultrasound: a cost analysis.European heart journal open · 2026Article
- Large-Scale Proteomic Profiling of Incident Heart Failure and Its Subtypes in Older Adults.Circulation. Genomic and precision medicine · 2026Article
- Alterations in Cardiac Structure and Function Associated With Sub-Severe Aortic Stenosis Progression: The ARIC Study.Journal of the American Heart Association · 2026Article
- Active endothelial and neural regulation of valve biology, health, and disease.Frontiers in cardiovascular medicine · 2026Review
- Differential Characteristics and Outcomes of Urgent/Emergent Versus Elective Aortic Valve Replacement.Journal of the American Heart Association · 2025Article
- Sleep disorders as risk factors for calcific aortic stenosis.American journal of preventive cardiology · 2025Article
- Plasma Proteomic Assessment of Calcific Aortic Valve Disease in Older Adults.Journal of the American Heart Association · 2025Article
- Atherosclerosis, calcific aortic valve disease and mitral annular calcification: same or different?International journal of cardiology · 2025Review
- Non-rheumatic calcific aortic valve disease in China: findings from the Global Burden of Disease study 2021.Frontiers in cardiovascular medicine · 2025Article
- Long-Term Outcome of Elderly Patients with Severe Aortic Stenosis Undergoing a Tailored Interventional Treatment Using Frailty-Based Management: Beyond the Five-Year Horizon.Journal of personalized medicine · 2024Article
- A Comprehensive Geriatric Workup and Frailty Assessment in Older Patients with Severe Aortic Stenosis.Journal of clinical medicine · 2024Review
- Traditional and novel risk factors for incident aortic stenosis in community-dwelling older adults.Heart (British Cardiac Society) · 2023Article
- Prognostic Impact of Mitral Regurgitation Before and After Transcatheter Aortic Valve Replacement in Patients With Severe Low-Flow, Low-Gradient Aortic Stenosis.Journal of the American Heart Association · 2023Article
- An Analysis of Early Results after Valve Replacement in Isolated Aortic Valve Stenosis by Using Sutureless vs. Stented Bioprostheses: A Single-Center Middle-Income Country Experience.Medicina (Kaunas, Lithuania) · 2023Article
- The Associations of Aortic Valve Sclerosis, Aortic Annular Increased Reflectivity, and Mitral Annular Calcification with Subsequent Aortic Stenosis in Older Individuals: Findings from the Cardiovascular Health Study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2023Article
- Caregiver Stress Is Improved and Sustained Following Transcatheter Aortic Valve Replacement.Palliative medicine reports · 2023Article
- Lipoproteins and Calcific Aortic Valve Disease: Hardening Evidence?Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- High-Density Lipoprotein and Long-Term Incidence and Progression of Aortic Valve Calcification: The Multi-Ethnic Study of Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Valvular disease burden in the modern era of percutaneous and surgical interventions: the UK Biobank.Open heart · 2022Article
- Impact of Managing Provider Type on Severe Aortic Stenosis Management and Mortality.Journal of the American Heart Association · 2022Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesCurrent estimates of aortic stenosis (AS) frequency have mostly relied on cross-sectional echocardiographic or longitudinal administrative data, making understanding of AS burden incomplete. We performed case adjudications to evaluate the frequency of AS and assess differences by age, sex and race in an older cohort with long-term follow-up.
methodsWe developed case-capture methods using study echocardiograms, procedure and diagnosis codes, heart failure events and deaths for targeted review of medical records in the Cardiovascular Health Study to identify moderate or severe AS and related procedures or hospitalisations. The primary outcome was clinically significant AS (severe AS or procedure). Assessment of incident AS burden was based on subdistribution survival methods, while associations with age, sex and race relied on cause-specific survival methods.
resultsThe cohort comprised 5795 participants (age 73±6, 42.2% male, 14.3% Black). Cumulative frequency of clinically significant AS at maximal 25-year follow-up was 3.69% (probable/definite) to 4.67% (possible/probable/definite), while the corresponding 20-year cumulative incidence was 2.88% to 3.71%. Of incident cases, about 85% had a hospitalisation for severe AS, but roughly half did not undergo valve intervention. The adjusted incidence of clinically significant AS was higher in men (HR 1.62 [95% CI 1.21 to 2.17]) and increased with age (HR 1.08 [95% CI 1.04 to 1.11]), but was lower in Blacks (HR 0.43 [95% CI 0.23 to 0.81]).
conclusionsIn this community-based study, we identified a higher burden of clinically significant AS than reported previously, with differences by age, sex and race. These findings have important implications for public health resource planning, although the lower burden in Blacks merits further study.
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