Evidence map›Paper›PMID 34083394›Full record

ArticleLife science alliance2021

A role for condensin in mediating transcriptional adaptation to environmental stimuli.

Lucy Lancaster, Harshil Patel, Gavin Kelly, Frank Uhlmann

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  8. Condensin Accelerates Long-Range Intra-Chromosomal Interactions.bioRxiv : the preprint server for biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lucy LancasterChromosome Segregation Laboratory, The Francis Crick Institute, London, UK.
Harshil PatelBioinformatics and Biostatistics Science Technology Platform, The Francis Crick Institute, London, UK.ORCID 0000-0003-2707-7940
Gavin KellyBioinformatics and Biostatistics Science Technology Platform, The Francis Crick Institute, London, UK.ORCID 0000-0001-7219-560X
Frank UhlmannChromosome Segregation Laboratory, The Francis Crick Institute, London, UK frank.uhlmann@crick.ac.uk.ORCID 0000-0002-3527-6619
The Francis Crick Institute · GB

Funding

Cancer Research UK 15671Cancer Research UK FC001198Medical Research Council FC001198Wellcome Trust FC001198
6 · The paper itself

Abstract

Nuclear organisation shapes gene regulation; however, the principles by which three-dimensional genome architecture influences gene transcription are incompletely understood. Condensin is a key architectural chromatin constituent, best known for its role in mitotic chromosome condensation. Yet at least a subset of condensin is bound to DNA throughout the cell cycle. Studies in various organisms have reported roles for condensin in transcriptional regulation, but no unifying mechanism has emerged. Here, we use rapid conditional condensin depletion in the budding yeast

Indexed as

Adenosine TriphosphatasesChromatinChromosomesChromosome SegregationDNADNA-Binding ProteinsGene ExpressionGene Expression RegulationMitosisMultiprotein ComplexesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAdenosine TriphosphatasesChromatincondensin complexesDNADNA-Binding ProteinsMultiprotein ComplexesSaccharomyces cerevisiae Proteins

Identifiers

PMID34083394
PMCPMC8200293
OpenAlexW3164610388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.