Evidence map›Paper›PMID 34082783›Full record

ArticleJournal of nanobiotechnology2021

Dielectric properties and lamellarity of single liposomes measured by in-liquid scanning dielectric microscopy.

Martina Di Muzio, Ruben Millan-Solsona, Aurora Dols-Perez, Jordi H Borrell, Laura Fumagalli, Gabriel Gomila

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Lipid Self-Assemblies under the Atomic Force Microscope.International journal of molecular sciences · 2021
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Martina Di MuzioInstitut de Bioenginyeria de Catalunya (IBEC), The Barcelona Institute of Science and Technology (BIST), c/Baldiri i Reixac 11-15, 08028, Barcelona, Spain.
Ruben Millan-SolsonaInstitut de Bioenginyeria de Catalunya (IBEC), The Barcelona Institute of Science and Technology (BIST), c/Baldiri i Reixac 11-15, 08028, Barcelona, Spain.
Aurora Dols-PerezInstitut de Bioenginyeria de Catalunya (IBEC), The Barcelona Institute of Science and Technology (BIST), c/Baldiri i Reixac 11-15, 08028, Barcelona, Spain.
Jordi H BorrellSecció de Fisicoquímica, Facultat de Farmàcia I Ciències de L'Alimentació, Universitat de Barcelona, Av. Diagonal, 643, 08028, Barcelona, Spain.
Laura FumagalliDepartment of Physics and Astronomy, University of Manchester, Manchester, M13 9PL, UK.
Gabriel GomilaInstitut de Bioenginyeria de Catalunya (IBEC), The Barcelona Institute of Science and Technology (BIST), c/Baldiri i Reixac 11-15, 08028, Barcelona, Spain. ggomila@ibecbarcelona.eu.ORCID http://orcid.org/0000-0002-1949-1757

Funding

Generalitat de Catalunya 2017-SGR1079H2020 European Research Council 819417H2020 Marie Skłodowska-Curie Actions H2020- MSCA-721874Ministerio de Economía, Industria y Competitividad, Gobierno de España PID2019-111376RA-I00
6 · The paper itself

Abstract

Liposomes are widely used as drug delivery carriers and as cell model systems. Here, we measure the dielectric properties of individual liposomes adsorbed on a metal electrode by in-liquid scanning dielectric microscopy in force detection mode. From the measurements the lamellarity of the liposomes, the separation between the lamellae and the specific capacitance of the lipid bilayer can be obtained. As application we considered the case of non-extruded DOPC liposomes with radii in the range ~ 100-800 nm. Uni-, bi- and tri-lamellar liposomes have been identified, with the largest population corresponding to bi-lamellar liposomes. The interlamellar separation in the bi-lamellar liposomes is found to be below ~ 10 nm in most instances. The specific capacitance of the DOPC lipid bilayer is found to be ~ 0.75 µF/cm

Indexed as

Drug CarriersMicroscopyDrug Delivery SystemsLipid BilayersLiposomesNanotechnologyDrug CarriersLipid BilayersLiposomesLamellarityLiposomesMembrane capacitanceNanoscaleScanning dielectric microscopy

Identifiers

PMID34082783
PMCPMC8176598

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.