Evidence map›Paper›PMID 34082782›Full record

ArticleRadiation oncology (London, England)2021

Cardiac-sparing radiotherapy for locally advanced non-small cell lung cancer.

Louise Turtle, Neeraj Bhalla, Andrew Willett, Robert Biggar, Jonathan Leadbetter, Georgios Georgiou, James M Wilson, Sindu Vivekanandan, Maria A Hawkins, Michael Brada and 1 more

Abstract read
In one paragraph

Article in Radiation oncology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Louise TurtleDepartment of Radiotherapy, The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, CH63 4JY, Wirral, UK. louise.turtle@nhs.net.ORCID http://orcid.org/0000-0003-3491-5033
Neeraj BhallaDepartment of Radiotherapy, The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, CH63 4JY, Wirral, UK.
Andrew WillettDepartment of Radiotherapy, The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, CH63 4JY, Wirral, UK.
Robert BiggarMedical Physics, Royal Devon and Exeter NHS Foundation Trust, Exeter, EX2 5DW, UK.
Jonathan LeadbetterDepartment of Radiotherapy, The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, CH63 4JY, Wirral, UK.
Georgios GeorgiouMolecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Royal Liverpool University Hospital, Liverpool, L69 3GA, UK.
James M WilsonMedical Physics and Biomedical Engineering, University College London, Gower Street, London, WC1E 6BT, UK.
Sindu VivekanandanGuy's and St. Thomas' NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK.
Maria A HawkinsMedical Physics and Biomedical Engineering, University College London, Gower Street, London, WC1E 6BT, UK.
Michael BradaDepartment of Radiotherapy, The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, CH63 4JY, Wirral, UK.
John D FenwickDepartment of Radiotherapy, The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, CH63 4JY, Wirral, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe have carried out a study to determine the scope for reducing heart doses in photon beam radiotherapy of locally advanced non-small cell lung cancer (LA-NSCLC). MATERIALS AND

methodsBaseline VMAT plans were created for 20 LA-NSCLC patients following the IDEAL-CRT isotoxic protocol, and were re-optimized after adding an objective limiting heart mean dose (MD

resultsFollowing re-optimization, mean MD

conclusionsCardiac irradiation in RT of LA-NSCLC can be reduced substantially. Of the measures studied, reduction of MD

Indexed as

Organ Sparing TreatmentsCarcinoma, Non-Small-Cell LungCoronary VesselsHeartHumansLung NeoplasmsOrgans at RiskRadiotherapy DosageRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedSurvival RateCardiac-sparingHeartNSCLCRadiotherapySurvival

Identifiers

PMID34082782
PMCPMC8176693

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.