ArticleBMC surgery2021
Analysis of risk factors and prognosis of 253 lymph node metastasis in colorectal cancer patients.
Article in BMC surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Development and validation of a model for predicting central lymph node metastasis in colorectal cancer based on CT textural features and clinical indicators.Translational cancer research · 2026Article
- A multinational pilot survey of clinical practice patterns in tumor-specific mesocolic excision and complete lymph node dissection for colorectal cancer.International journal of clinical oncology · 2026Article
- Exploring the relationship between Alzheimer's disease and colorectal/breast cancers using SEER database, Mendelian randomization, and transcriptomic data.Discover oncology · 2026Article
- The prognostic significance of metastasis to No. 253 lymph node in stage III rectal cancer based on a bicenter retrospective study.Scientific reports · 2026Article
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- Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy outcomes in peritoneal carcinomatosis: 11-year tertiary-center experience.BMC cancer · 2025Article
- Article
- Mono+ algorithm assessment of the diagnostic value of dual-energy CT for high-risk factors for colorectal cancer: a preliminary study.Quantitative imaging in medicine and surgery · 2024Article
- A Study on Lymph Node Distribution in the Main Lymph Node Area for Left-sided Colon Cancer.Journal of the anus, rectum and colon · 2024Article
- Differential expression of PLAC1 and Netrin-1 in liver metastasis of colorectal cancer and its predictive value.BMC gastroenterology · 2023Article
- Rectal Cancer: Are 12 Lymph Nodes the Limit?Cancers · 2023Article
- Correlation of INHBA Overexpression with Pathological Features, Antitumor Immune Response and Clinical Prognosis in Cervical Cancer.Medicina (Kaunas, Lithuania) · 2023Article
- Short- and long-term outcomes of preservation versus ligation of the inferior mesenteric artery in laparoscopic D3 lymph node dissection for descending colon cancer: a propensity score-matched analysis.Langenbeck's archives of surgery · 2023Article
- High serum mannose in colorectal cancer: a novel biomarker of lymph node metastasis and poor prognosis.Frontiers in oncology · 2023Article
- Development and validation of a survival prediction model for 113,239 patients with colon cancer: a retrospective cohort study.Journal of gastrointestinal oncology · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to explore potential risk factors for 253 lymph node metastasis, and to identify the prognostic impact of 253 lymph node metastasis in colorectal cancer patients.
methodsA retrospective study was conducted of 391 colorectal cancer patients who underwent surgical treatments that included 253 lymph node dissection. Clinicopathological features, molecular indexes and 1-year overall survival rates were analyzed.
resultsUnivariate analyses revealed the following risk factors for 253 lymph node metastasis: high preoperative levels of CEA, large tumour max diameters, and numbers of harvested lymph nodes, presence of vessel carcinoma emboli, low level of MSH6 and MLH1 immunohistochemical staining intensity. Multivariate analysis showed that elevated MLH1 immunohistochemical staining intensity was an independent protective factor for 253 lymph node metastasis (OR: 0.969, 95% CI 0.945, 0.994, P = 0.015). A significant difference was found in 1-year overall survival rate between 253 lymph node-positive and lymph node-negative colorectal cancer patients (88.9% vs.75.0%, P < 0.001).
conclusions253 lymph node-positive colorectal cancer patients had a worse prognosis than the 253 lymph node-negative patients. 253 lymph node dissection may improve the prognosis of colorectal cancer patients with high risk factors for 253 lymph node metastasis.
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