Evidence map›Paper›PMID 34082648›Full record

ArticleBioengineered2021

MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2).

Huang Jinghua, Zhou Qinghua, Chen Chenchen, Chen Lili, Xu Xiao, Wang Yunfei, An Zhengzhe, Lin Changxiu, Han Hui

Abstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huang JinghuaDepartment of Radiation Oncology, Affiliated Hospital of Yanbian University, Yanbian, Jilin, China.
Zhou QinghuaDepartment of Pain Control, Zoucheng People 'S Hospital, Shandong, China.
Chen ChenchenDepartment of Gynecology, Affiliated Hospital of Jining Medical University. Jining, Shandong, China.
Chen LiliDepartment of Anesthesiology, Huaiyin People's Hospital, Huaiyin District, Jinan, Shandong, China.
Xu XiaoDepartment of Gynecology, Affiliated Hospital of Jining Medical University. Jining, Shandong, China.
Wang YunfeiDepartment of Gynecology, Affiliated Hospital of Jining Medical University. Jining, Shandong, China.
An ZhengzheDepartment of Radiation Oncology, Affiliated Hospital of Yanbian University, Yanbian, Jilin, China.
Lin ChangxiuCentral Laboratory, Affiliated Hospital of Yanbian University, Yanbian, Jilin, China.
Han HuiDepartment of Gynecology, Affiliated Hospital of Jining Medical University. Jining, Shandong, China.ORCID 0000-0003-2097-1085

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) dysregulation contributes to tumorigenesis, and it is reported that abnormal miR-92a-3p expression participates in multiple cancers' occurrence and progression. This study focuses on miR-92a-3p's functions and regulatory mechanism in breast cancer (BC). The current study proved miR-92a-3p expression was enhanced in BC tissues and cells, and its high expression was related to increased TNM stage and larger tumor size of BC patients. Functionally, transfection of miR-92a-3p mimics facilitated BC cell proliferation and metastasis, yet transfection of miR-92a-3p inhibitors functioned oppositely. In addition, BTG2 was verified as a direct miR-92a-3p target in BC cells. This research indicated that miR-92a-3p facilitates BC cell proliferation and metastasis through repressing BTG2 expression.

Indexed as

Breast NeoplasmsBreastCell Line, TumorCell ProliferationFemaleHumansImmediate-Early ProteinsMicroRNAsMiddle AgedNeoplasm MetastasisTumor Suppressor ProteinsBTG2 protein, humanImmediate-Early ProteinsMicroRNAsMIRN92 microRNA, humanTumor Suppressor ProteinsBreast cancerBTG2miR-92a-3p

Identifiers

PMID34082648
PMCPMC8806219

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.