ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2021
Exposure to pesticides and oxidative stress in Brazilian agricultural communities.
Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 18 citations in OpenAlex.
- The association between glyphosate use and mosaic loss of chromosome Y in buccal samples among male pesticide applicators in the Agricultural Health Study.Environment international · 2025Article
- Glyphosate Use and Mosaic Loss of Chromosome Y among Male Farmers in the Agricultural Health Study.Environmental health perspectives · 2023Article
- Glyphosate exposure and urinary oxidative stress biomarkers in the Agricultural Health Study.Journal of the National Cancer Institute · 2023Article
- Prostaglandin Metabolome Profiles in Zebrafish (International journal of molecular sciences · 2023Article
- Health Effects of Pesticide Exposure in Latin American and the Caribbean Populations: A Scoping Review.Environmental health perspectives · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundOxidative stress may be an important mechanism linking pesticide exposure to several diseases. We evaluated the association between pesticide exposures and oxidative stress biomarkers in Brazilian agricultural workers.
methodsA cross-sectional study was conducted in healthy agricultural (N = 52) and non-agricultural workers (N = 68) in a rural community in Rio de Janeiro State, Brazil. Regular pesticide use, sociodemographic, and lifestyle information was obtained by questionnaire. Oxidative stress biomarkers (N = 7) were measured in serum and plasma. We calculated percent differences and 95% confidence intervals (CI) in oxidative stress biomarkers for use of pesticides adjusted for sex, age, education, smoking, and alcohol consumption, using multiple linear regression.
resultsLiving close to or in the fields was associated with glutathione peroxidase activity but not with any other markers. We observed significant positive associations between 8-isoprostane levels and activities of glutathione reductase, glutathione peroxidase, and glutathione-S-transferase with reported use of certain insecticides, fungicides, and herbicides. Our results also indicate a significant and negative association between glutathione-S-transferase activity and insecticide use.
conclusionsThese findings suggest that use of pesticides may be associated with differences in oxidative stress biomarkers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.