Evidence map›Paper›PMID 34082252›Full record

SynthesisJournal of critical care2021

COVID-19-related echocardiographic patterns of cardiovascular dysfunction in critically ill patients: A systematic review of the current literature.

Antonio Messina, Filippo Sanfilippo, Angelo Milani, Lorenzo Calabrò, Katerina Negri, Manuel Ignacio Monge García, Marinella Astuto, Antoine Vieillard-Baron, Maurizio Cecconi

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Journal of critical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Antonio MessinaHumanitas Clinical and Research Center - IRCCS, Milano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy. Electronic address: antonio.messina@humanitas.it.
Filippo SanfilippoDepartment of Anaesthesia and Intensive Care, AOU. "Policlinico-San Marco", Catania, Italy.
Angelo MilaniHumanitas Clinical and Research Center - IRCCS, Milano, Italy.
Lorenzo CalabròHumanitas Clinical and Research Center - IRCCS, Milano, Italy.
Katerina NegriDepartment of Health Sciences, University of Milan, Milano, Italy.
Manuel Ignacio Monge GarcíaUnidad de Cuidados Intensivos, Hospital Universitario SAS de Jerez, Jerez de la Frontera, Spain.
Marinella AstutoDepartment of Anaesthesia and Intensive Care, AOU. "Policlinico-San Marco", Catania, Italy; School of Anaesthesia and Intensive Care, University Hospital "G. Rodolico", University of Catania, Catania, Italy.
Antoine Vieillard-BaronIntensive Care Medicine Unit, Assistance Publique-Hôpitaux de Paris, University Hospital Ambroise, Boulogne-Billancourt, INSERM UMR-1018, CESP, Team Kidney and Heart, University of Versailles Saint-Quentin en Yvelines, Villejuif, France.
Maurizio CecconiHumanitas Clinical and Research Center - IRCCS, Milano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.
Humanitas University · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITPoliclinico Universitario di Catania · ITUniversité de Versailles Saint-Quentin-en-Yvelines · FRUniversity of Catania · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCoronavirus disease 2019 (COVID-19) infection may trigger a multi-systemic disease involving different organs. There has been growing interest regarding the harmful effects of COVID-19 on the cardiovascular system. This systematic review aims to systematically analyze papers reporting echocardiographic findings in hospitalized COVID-19 subjects. MATERIALS AND

methodsWe included prospective and retrospective studies reporting echocardiography data in >10 hospitalized adult subjects with COVID-19; from 1st February 2020 to 15th January 2021.

resultsThe primary electronic search identified 1120 articles. Twenty-nine studies were finally included, enrolling 3944 subjects. Overall the studies included a median of 68.0% (45.5-100.0) of patients admitted to ICU. Ten studies (34.4%) were retrospective, and 20 (68.9%) single-centred. Overall enrolling 1367 subjects, three studies reported normal echocardiographic findings in 49 ± 18% of cases. Seven studies (24.1%) analyzed the association between echocardiographic findings and mortality, mostly related to right ventricular (RV) dysfunction.

conclusionsData regarding the use of echocardiography on hospitalized, predominantly ICU, COVID-19 patients were retrieved from studies with heterogeneous designs, variable sample sizes, and severity scores. Normal echocardiographic findings were reported in about 50% of subjects, with LVEF usually not affected. Overall, RV dysfunction seems more likely associated with increased mortality.

trial registrationCRD42020218439.

Indexed as

COVID-19Critical IllnessAdultEchocardiographyHumansProspective StudiesRetrospective StudiesSARS-CoV-2COVID-19Critical careDiastolic functionEchocardiographyLeft ventricleRight ventricleSystolic function

Identifiers

PMID34082252
PMCPMC8146405
OpenAlexW3164817538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.