Evidence map›Paper›PMID 34082001›Full record

ArticleJournal of vascular surgery2021

Claudicating patients with peripheral artery disease have meaningful improvement in walking speed after supervised exercise therapy.

Hafizur Rahman, Iraklis I Pipinos, Jason M Johanning, George Casale, Mark A Williams, Jonathan R Thompson, Yohanis O'Neill-Castro, Sara A Myers

Open access · bronzeAbstract read
In one paragraph

Article in Journal of vascular surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Hafizur RahmanDepartment of Biomechanics, University of Nebraska at Omaha, Omaha, Neb; Department of Surgery and Research Service, Veterans' Affairs Medical Center of Nebraska and Western Iowa, Omaha, Neb. Electronic address: hrahman@unomaha.edu.
Iraklis I PipinosDepartment of Surgery and Research Service, Veterans' Affairs Medical Center of Nebraska and Western Iowa, Omaha, Neb; Department of Surgery, University of Nebraska Medical Center, Omaha, Neb.
Jason M JohanningDepartment of Surgery and Research Service, Veterans' Affairs Medical Center of Nebraska and Western Iowa, Omaha, Neb; Department of Surgery, University of Nebraska Medical Center, Omaha, Neb.
George CasaleDepartment of Surgery, University of Nebraska Medical Center, Omaha, Neb.
Mark A WilliamsDepartment of Medicine, Creighton University School of Medicine, Omaha, Neb.
Jonathan R ThompsonDepartment of Surgery, University of Nebraska Medical Center, Omaha, Neb.
Yohanis O'Neill-CastroDepartment of Surgery, University of Nebraska Medical Center, Omaha, Neb.
Sara A MyersDepartment of Biomechanics, University of Nebraska at Omaha, Omaha, Neb; Department of Surgery and Research Service, Veterans' Affairs Medical Center of Nebraska and Western Iowa, Omaha, Neb.
University of Nebraska Medical Center · USNebraska Medical Center · USUniversity of Nebraska at Omaha · USCreighton University · US

Funding

Mitochondrial dysfunction, oxidative damage and inflammation in claudicationR01AG034995 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PIPINOS, IRAKLIS ILIAS · 2010 to 2014
$5.2M
Ramipril treatment of claudication: oxidative damage and muscle fibrosisR01AG049868 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CASALE, GEORGE PASCO, PIPINOS, IRAKLIS ILIAS · 2015 to 2019
$4.7M
Improving mobility in peripheral artery disease using an ankle foot orthosisR01HD090333 · NICHD · UNIVERSITY OF NEBRASKA OMAHA · PI MYERS, SARA A · 2016 to 2020
$2.1M
Gait after intervention trial in peripheral arterial diseaseI01RX000604 · VA · OMAHA VA MEDICAL CENTER · PI JOHANNING, JASON MICHAEL · 2015 to 2016
–
Exoskeleton footwear to improve walking performance and subject-reported preference.I01RX003266 · VA · OMAHA VA MEDICAL CENTER · PI MYERS, SARA A, PIPINOS, IRAKLIS ILIAS · 2020 to 2024
–
NIA NIH HHS R01 AG034995NIA NIH HHS R01 AG049868NICHD NIH HHS R01 HD090333RRD VA I01 RX000604RRD VA I01 RX003266
6 · The paper itself

Abstract

objectiveSupervised exercise therapy (SET) is a first-line treatment for patients with peripheral artery disease (PAD). The efficacy of SET is most commonly expressed by significant statistical improvement of parameters that do not clarify how each individual patient will benefit from SET. This study examined the minimal clinically important difference (MCID) in walking speed in claudicating patients with PAD after SET.

methodsA total of 63 patients with PAD-related claudication (Fontaine stage II PAD) participated in a 6-month SET program. Self-selected walking speed was measured before and after SET. Distribution and anchor-based approaches were used to estimate the MCID for small and substantial improvement. The ability to walk one block and the ability to climb one flight of stairs questions were chosen as anchor questions from the Medical Outcomes Study 36-item Short Form questionnaire. Receiver operating characteristics curve analyses were performed to detect the threshold for MCID in walking speed after treatment.

resultsThe distribution-based method estimated 0.03 m/s as a small improvement and 0.08 m/s as a substantial improvement after SET. Small and substantial improvements according to the anchor question walking one block were 0.05 m/s and 0.15 m/s, respectively. For the climbing one flight of stairs anchor question, 0.10 m/s was a small improvement. Receiver operating characteristics curve analyses identified an increase of 0.04 m/s and 0.03 m/s for improvement based on walking one block and climbing one flight of stairs, respectively.

conclusionsWe report our findings for the MCID for walking speed among claudicating patients receiving SET. Claudicating patients who increase walking speed of 0.03 m/s or greater are more likely to experience a meaningful improvement in walking impairment than those who do not. The MCID reported in this study can serve as a benchmark for clinicians to develop goals and interpret clinically meaningful progress in the care of claudicating patients with PAD.

Indexed as

Exercise TherapyWalking SpeedAgedFunctional StatusHumansIntermittent ClaudicationLongitudinal StudiesMaleMiddle AgedMinimal Clinically Important DifferencePeripheral Arterial DiseaseRecovery of FunctionRetrospective StudiesTime FactorsTreatment OutcomeWalk TestMinimal clinically important differencePeripheral artery diseaseSupervised exercise therapyWalking speed

Identifiers

PMID34082001
PMCPMC8612940
OpenAlexW3164810403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.