Evidence map›Paper›PMID 34081922›Full record

ArticleCell2021

Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.

Evangelos Giampazolias, Oliver Schulz, Kok Haw Jonathan Lim, Neil C Rogers, Probir Chakravarty, Naren Srinivasan, Oliver Gordon, Ana Cardoso, Michael D Buck, Enzo Z Poirier and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.

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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Evangelos GiampazoliasImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Oliver SchulzImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Kok Haw Jonathan LimImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Immunology and Inflammation, Imperial College London, Du Cane Road, London W12 0NN, UK.
Neil C RogersImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Probir ChakravartyBioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Naren SrinivasanImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Oliver GordonImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Ana CardosoImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Michael D BuckImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Enzo Z PoirierImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Johnathan CantonImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Santiago ZelenayImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Stefano SammicheliImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Natalia MoncautGenetic Modification Services, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Sunita Varsani-BrownGenetic Modification Services, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Ian RosewellGenetic Modification Services, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Caetano Reis e SousaImmunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: caetano@crick.ac.uk.
The Francis Crick Institute · GB

Funding

Cancer Research UK 22255Wellcome Trust 106973/Z/15/ZWellcome Trust 216327/Z/19/ZWellcome Trust FC001136
6 · The paper itself

Abstract

Cross-presentation of antigens from dead tumor cells by type 1 conventional dendritic cells (cDC1s) is thought to underlie priming of anti-cancer CD8

Indexed as

ImmunityActinsAmino Acid SequenceAnimalsAntigens, NeoplasmCD8-Positive T-LymphocytesCell MovementCell ProliferationCross-PrimingCytoskeletonDendritic CellsGelsolinGene Expression Regulation, NeoplasticImmune Checkpoint InhibitorsLectins, C-TypeMiceActinsAntigens, NeoplasmCLEC9a protein, humanClec9a protein, mouseGelsolinImmune Checkpoint InhibitorsLectins, C-TypeReceptors, ImmunologicReceptors, Mitogencancer immunityCLEC9Across-presentationdendritic cellsDNGR-1F-actinsecreted gelsolin

Identifiers

PMID34081922
PMCPMC8320529
OpenAlexW3164023991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.