Evidence map›Paper›PMID 34081864›Full record

ArticleJournal of the American Chemical Society2021

High-Fidelity Sequence-Selective Duplex Formation by Recognition-Encoded Melamine Oligomers.

Pavle Troselj, Peter Bolgar, Pablo Ballester, Christopher A Hunter

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Sequence-Dependent Folding of Recognition-Encoded Melamine Oligomers.Journal of the American Chemical Society · 2026
    Article
  3. Article
  4. Recognition-Encoded Molecules: A Minimal Self-Replicator.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Synthetically encoded complementary oligomers.Nature reviews. Chemistry · 2023
    Review
  10. Peptide Macrocyclization Guided by Reversible Covalent Templating.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  11. Article
  12. Directional Ionic Bonds.Journal of the American Chemical Society · 2023
    Article
  13. Recognition-Encoded Synthetic Information Molecules.Accounts of chemical research · 2023
    Article
  14. Article
  15. H-Bond Templated Oligomer Synthesis Using a Covalent Primer.Journal of the American Chemical Society · 2022
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pavle TroseljYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
Peter BolgarYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
Pablo BallesterInstitute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.ORCID 0000-0001-8377-6610
Christopher A HunterYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.ORCID 0000-0002-5182-1859

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melamine oligomers composed of repeating triazine-piperidine units and equipped with phenol and phosphine oxide side-chains form H-bonded duplexes. The melamine backbone provides sufficient rigidity to prevent intramolecular folding of oligomers up to three recognition units in length, leading to reliable duplex formation between sequence complementary oligomers. NMR spectroscopy and isothermal titration calorimetry (ITC) were used to characterize the self-assembly properties of the oligomers. For length-complementary homo-oligomers, duplex formation in toluene is characterized by an increase in stability of an order of magnitude for every base-pair added to the chain. NMR spectra of dilute solutions of the

Identifiers

PMID34081864
PMCPMC8213060

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.