Evidence map›Paper›PMID 34081400›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Photoacoustic Force-Guided Precise and Fast Delivery of Nanomedicine with Boosted Therapeutic Efficacy.

Jun Wang, Tingting Li, Jen-Shyang Ni, Heng Guo, Tianyi Kang, Zeshun Li, Menglei Zha, Songbo Lu, Chen Zhang, Weizhi Qi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jun WangDepartment of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China.
Tingting LiDepartment of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China.
Jen-Shyang NiDepartment of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China.
Heng GuoDepartment of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China.
Tianyi KangDepartment of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China.
Zeshun LiDepartment of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China.
Menglei ZhaDepartment of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China.
Songbo LuDepartment of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China.
Chen ZhangDepartment of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China.
Weizhi QiDepartment of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China.
Lei XiDepartment of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China.
Kai LiDepartment of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China.ORCID 0000-0003-1664-5439

Funding

Department of Science and Technology of Guangdong Province 2019QN01Y640Department of Science and Technology of Guangdong Province 2019ZT08Y191Department of Science and Technology of Guangdong Province SZBL2020090501013Ministry of Science and Technology of China 2020YFA0908900National Natural Science Foundation of China 31870991National Natural Science Foundation of China 61528401National Natural Science Foundation of China 61775028National Natural Science Foundation of China 62022037National Natural Science Foundation of China 81571722Shenzhen Key Laboratory of Smart Healthcare Engineering ZDSYS20200811144003009Shenzhen Science and Technology Program JCYJ20200109141222892Shenzhen Science and Technology Program JSGG20200225151916021Shenzhen Science and Technology Program KQTD20190929172743294
6 · The paper itself

Abstract

Precise and efficient delivery of nanomedicine to the target site has remained as a major roadblock in advanced cancer treatment. Here, a novel photoacoustic force (PAF)-guided nanotherapeutic system is reported based on a near-infrared (NIR)-absorbing semiconducting polymer (SP), showing significantly improved tumor accumulation and deep tissue penetration for enhanced phototherapeutic efficacy. The accumulation of nanoparticles in 4T1 tumor-bearing mice induced by the PAF strategy displays a fivefold enhancement in comparison with that of the traditional passive targeting pathway, in a significantly shortened time (45 min vs 24 h) with an enhanced penetration depth in tumors. Additionally, a tumor-bearing mouse model is rationally designed to unveil the mechanism, indicating that the nanoparticles enter solid tumors through enhanced transportation across blood vessel barriers via both inter-endothelial gaps and active trans-endothelial pathways. This process is specifically driven by PAF generated from the nanoparticles under NIR laser irradiation. The study thus demonstrates a new nanotherapeutic strategy with low dose, enhanced delivery efficiency in tumor, and boosted therapeutic efficacy, opening new doors for designing novel nanocarriers.

Indexed as

AnimalsCell Line, TumorDisease Models, AnimalMiceNanomedicineNeoplasmsPhotoacoustic Techniquesnanomedicine deliveryphotoacoustic forcephotodynamic therapyphotothermal therapysemiconducting polymer

Identifiers

PMID34081400
PMCPMC8373104

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.