ArticleJournal of medical virology2021
Vertical transmission of SARS-CoV-2: A prospective cross-sectional study from a tertiary center.
Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Neonatal outcomes among pregnant women with COVID-19: a systematic scoping review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Viral shedding of SARS-CoV-2 in body fluids associated with sexual activity: a systematic review and meta-analysis.BMJ open · 2024Pooled it
- Pooled it
- Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature.Frontiers in medicine · 2022Pooled it
- BM study: a monocentric prospective observational cohort study on neonatal humoral immunity against COVID-19 secondary to transplacental antibody transfer and breastfeeding.Italian journal of pediatrics · 2025Observational
- Impact of SARS-CoV-2 infection during pregnancy on the placenta and fetus.Seminars in perinatology · 2024Review
- Comparison of Anti-SARS-CoV-2-Specific Antibody Signatures in Maternal and Infant Blood after COVID-19 Infection versus COVID-19 Vaccination during Pregnancy.American journal of perinatology · 2024Article
- Investigating the mode of transmission of COVID-19 through genital secretions, semen, the birth canal, and lactation: A systematic review.Journal of education and health promotion · 2024Article
- Maternal SARS-CoV-2 infection: The potential vertical transmission of SARS-CoV-2 and impact on neonates: A review.Pediatric discovery · 2023Review
- Inflammation and Immune Reactions in the Fetus as a Response to COVID-19 in the Mother.Journal of clinical medicine · 2023Article
- Investigation of SARS-CoV-2 using RT-PCR in vaginal swab samples of female patients with a diagnosis of severe COVID-19.Taiwanese journal of obstetrics & gynecology · 2023Article
- The Impact of Coronavirus Disease 2019 on Maternal and Fetal Wellbeing in New Mexico.Diagnostics (Basel, Switzerland) · 2022Article
- Risk of vertical transmission of SARS CoV-2 infection to neonates born to covid positive mothers: A pilot study from a tertiary care hospital of North India.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2022Article
- Clinical Manifestation and Obstetric Outcomes in Pregnant Women with SARS-CoV-2 Infection at Delivery: A Retrospective Cohort Analysis.Journal of personalized medicine · 2022Article
- Transgenerational epigenetic impacts of parental infection on offspring health and disease susceptibility.Trends in genetics : TIG · 2022Review
- Post-COVID-19 fetal cardiac evaluation in moderate infection group of pregnant women.Journal of clinical ultrasound : JCU · 2022Article
- Associations and Disease-Disease Interactions of COVID-19 with Congenital and Genetic Disorders: A Comprehensive Review.Viruses · 2022Review
- Circulation of SARS-CoV-2 Variants among Children from November 2020 to January 2022 in Trieste (Italy).Microorganisms · 2022Article
- Mixed Intervillositis in SARS-CoV-2 Infection Associated with Fetal Death: A Case Report.Case reports in obstetrics and gynecology · 2022Article
- Research progresses in vertical transmission of SARS-CoV-2 among infants born to mothers with COVID-19.Future virology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim was to investigate the association of the delivery mode and vertical transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) through the samples of vaginal secretions, placenta, cord blood, or amniotic fluid as well as the neonatal outcomes. This cross-sectional study presents an analysis of prospectively gathered data collected at a single tertiary hospital. Sixty-three pregnant women with confirmed coronavirus disease 2019 (COVID-19) participated in the study. Vertical transmission of SARS-CoV-2 was analyzed with reverse transcriptase-polymerase chain reaction (RT-PCR) tests and blood tests for immunoglobulin G (IgG)-immunoglobulin M (IgM) antibodies. All patients were in the mild or moderate category for COVID-19. Only one placental sample and two of the vaginal secretion samples were positive for SARS-CoV-2. Except for one, all positive samples were obtained from patients who gave birth by cesarean. All cord blood and amniotic fluid samples were negative for SARS-CoV-2. Two newborns were screened positive for COVID-19 IgG-IgM within 24 h after delivery, but the RT-PCR tests were negative. A positive RT-PCR result was detected in a neof a mother whose placenta, cord blood, amniotic fluid, and vaginal secretions samples were negative. He died due to pulmonary hemorrhage on the 11th day of life. In conclusion, we demonstrated that SARS-CoV-2 can be detectable in the placenta or vaginal secretions of pregnant women. Detection of the virus in the placenta or vaginal secretions may not be associated with neonatal infection. Vaginal delivery may not increase the incidence of neonatal infection, and cesarean may not prevent vertical transmission. The decision regarding the mode of delivery should be based on obstetric indications and COVID-19 severity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.