Evidence map›Paper›PMID 34081299›Full record

ArticleJournal of autism and developmental disorders2022

Empathy and Anxiety in Young Girls with Fragile X Syndrome.

Jonas G Miller, Kristi L Bartholomay, Cindy H Lee, Jennifer L Bruno, Amy A Lightbody, Allan L Reiss

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jonas G MillerDepartment of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA. jgmiller@stanford.edu.ORCID http://orcid.org/0000-0001-7061-3900
Kristi L BartholomayDepartment of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA.
Cindy H LeeDepartment of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA.
Jennifer L BrunoDepartment of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA.
Amy A LightbodyDepartment of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA.
Allan L ReissDepartment of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA.
Stanford University · US

Funding

Cooperative Agreement for a Nat'l Research & Training Org for People with DevelopU01DD000231 · DD · ASSN OF UNIVERSITY CENTERS/ DISABILITIES · PI JESIEN, GEORGE S. · 2007 to 2012
$16.8M
NEUROPSYCHIATRIC-MOLECULAR ASSOCIATIONS IN FRAGILE X SYNR01MH050047 · NIMH · STANFORD UNIVERSITY · PI REISS, ALLAN L · 1993 to 2022
$12.5M
TRAINING FOR CHILD PSYCHIATRY AND CHILD DEVELOPMENTT32MH019908 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB, DAVID S HONG · 1993 to 2026
$6.3M
Pilot Longitudinal Data Collection to Inform Public Health_Fragile X SyndromeU19DD000753 · DD · INSTITUTE FOR BASIC RES IN DEV DISABIL · PI BROWN, WILLIAM TED · 2011 to 2014
$2.3M
NCBDD CDC HHS U01 DD000231NCBDD CDC HHS U01 DD001189NCBDD CDC HHS U19 DD000753NIMH NIH HHS R01 MH050047NIMH NIH HHS R01MH050047-20NIMH NIH HHS T32 MH019908NIMH NIH HHS T32MH019908
6 · The paper itself

Abstract

We tested whether empathy is impaired and associated with anxiety in girls with fragile X syndrome (FXS). We measured parent-reported empathy and self-reported anxiety in young girls with FXS and in a developmentally-matched comparison group. Girls with FXS received higher parent-reported scores on cognitive and affective empathy but also self-reported more severe anxiety symptoms, particularly separation anxiety and phobia symptoms, than girls in the comparison group. Girls with FXS who received higher cognitive empathy scores, however, appeared buffered against risk for separation anxiety and phobia symptoms. Girls with FXS experience elevated empathy and anxiety relative to their developmentally-matched peers. Higher cognitive empathy in girls with FXS may indicate resilience against specific forms of anxiety that are commonly observed in FXS.

Indexed as

Autism Spectrum DisorderFragile X SyndromeAnxietyAnxiety DisordersEmpathyFemaleHumansAdolescenceAnxietyChildhoodEmpathyFemalesFragile X syndrome

Identifiers

PMID34081299
PMCPMC8639840
OpenAlexW3160922189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.