SynthesisHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2021
The Impact of Chromium Supplementation on Blood Pressure: A Systematic Review and Dose-Response Meta‑Analysis of Randomized‑Controlled Trials.
Synthesis in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between blood selenium and metabolic syndrome in adults: a systematic review and dose-response meta-analysis of epidemiologic studies.Frontiers in nutrition · 2024Pooled it
- The Effect of Chromium Picolinate Supplementation on Cardiometabolic Biomarkers, Tumor Necrosis Factor-α Gene Expression, and DNA Damage in Subjects with Metabolic Syndrome: a Randomized Placebo-Controlled Clinical Trial.Biological trace element research · 2026Trial
- Is the antihypertensive activity of Hibiscus sabdariffa affected by factors such as origin of the plant and time of decoction? Implications for clinical practice.Journal of human hypertension · 2026Article
- Impact of multi-metal exposure on blood pressure: a mediation analysis through oxidative stress markers in China's Southern Jiangxi Province.BMC public health · 2025Article
- The association between the urinary chromium and blood pressure: a population-based study.BMC cardiovascular disorders · 2024Article
- Interactive Effects of Obesity and Hypertension on Patterns of Hair Essential Trace Element and Mineral Content in Adult Women.Biological trace element research · 2023Article
- Metallomics in pulmonary arterial hypertension patients.Pulmonary circulation · 2023Article
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Authors and funding
4 authors.
Funding
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Abstract
introductionPotential effects of chromium supplementation on blood pressure (BP) have been examined in several interventional studies. Nevertheless, findings in this context are controversial.
aimTherefore, the current systematic review and meta-analysis aimed to comprehensively assess the impact of chromium supplementation on BP.
methodsFive online databases including Web of Science, Scopus, Embase, Google Scholar, and PubMed were systematically searched from inception to March 2020. We included all randomized clinical trials (RCTs) evaluating the effects of chromium supplementation on systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) in humans.
resultsThe random-effects meta-analysis of 11 eligible RCTs with 637 participants demonstrated the significant decline in both SBP (WMD - 2.51 mmHg; 95% CI - 4.97 to - 0.05, p = 0.04) and DBP (WMD - 1.04 mmHg; 95% CI - 1.96 to - 0.12, p = 0.026) following supplementation with chromium. In subgroup analysis, studies that were administered chromium yeast and brewer's yeast, showed greater decrease in SBP. Also, in stratification based on participants' health status, significant reduction in SBP only was seen in diabetic patients with chronic heart disease (CHD). Nonlinear dose-response analysis revealed a significant influence of chromium dosage on SBP changes.
conclusionThe current meta-analysis, indicated that supplementation with chromium significantly decrease SBP and DBP. In subgroup analysis, administration of chromium yeast and brewer's yeast resulted in greater reduction in SBP. Further large-scale RCTs with better design are needed to confirm these findings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.