Evidence map›Paper›PMID 34081211›Full record

ReviewCurrent cardiology reports2021

Diabetes and Cardiovascular Complications: The Epidemics Continue.

Raquel López-Díez, Lander Egaña-Gorroño, Laura Senatus, Alexander Shekhtman, Ravichandran Ramasamy, Ann Marie Schmidt

Open access · hybridAbstract readReview
In one paragraph

Review in Current cardiology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Raquel López-DíezDiabetes Research Program, Department of Medicine, New York University Grossman School of Medicine, 435 East 30th Street, Science Building, Room 615, New York, NY, 10016, USA.
Lander Egaña-GorroñoDiabetes Research Program, Department of Medicine, New York University Grossman School of Medicine, 435 East 30th Street, Science Building, Room 615, New York, NY, 10016, USA.
Laura SenatusDiabetes Research Program, Department of Medicine, New York University Grossman School of Medicine, 435 East 30th Street, Science Building, Room 615, New York, NY, 10016, USA.
Alexander ShekhtmanDepartment of Chemistry, The State University of New York at Albany, Albany, NY, USA.
Ravichandran RamasamyDiabetes Research Program, Department of Medicine, New York University Grossman School of Medicine, 435 East 30th Street, Science Building, Room 615, New York, NY, 10016, USA.
Ann Marie SchmidtDiabetes Research Program, Department of Medicine, New York University Grossman School of Medicine, 435 East 30th Street, Science Building, Room 615, New York, NY, 10016, USA. annmarie.schmidt@nyulangone.org.ORCID http://orcid.org/0000-0001-8902-070X
New York University · USUniversity at Albany, State University of New York · US

Funding

Resolving Macrophage Inflammation in Atherosclerotic Plaques and Other Sites in Insulin ResistanceP01HL131481 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANN MARIE SCHMIDT · 2017 to 2026
$27.3M
Project 3: RAGE/DIAPH1 interactions and cellular stressP01HL146367 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SCHMIDT, ANN MARIE · 2019 to 2023
$12.5M
RAGE/mDia1, Macrophage Trafficking and Inflammation in High Fat FeedingR01DK109675 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RAMASAMY, RAVICHANDRAN, SCHMIDT, ANN MARIE · 2016 to 2020
$2.6M
RAGE/mDia1, Macrophage Trafficking and Inflammation in Regression of Diabetic AtherosclerosisR01HL132516 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RAMASAMY, RAVICHANDRAN, SCHMIDT, ANN MARIE · 2017 to 2020
$2.5M
NHLBI NIH HHS P01 HL131481NHLBI NIH HHS P01 HL146367NHLBI NIH HHS R01 HL132516NIDDK NIH HHS R01 DK109675
6 · The paper itself

Abstract

purpose of reviewThe cardiovascular complications of type 1 and 2 diabetes are major causes of morbidity and mortality. Extensive efforts have been made to maximize glycemic control; this strategy reduces certain manifestations of cardiovascular complications. There are drawbacks, however, as intensive glycemic control does not impart perennial protective benefits, and these efforts are not without potential adverse sequelae, such as hypoglycemic events. RECENT

findingsHere, the authors have focused on updates into key areas under study for mechanisms driving these cardiovascular disorders in diabetes, including roles for epigenetics and gene expression, interferon networks, and mitochondrial dysfunction. Updates on the cardioprotective roles of the new classes of hyperglycemia-targeting therapies, the sodium glucose transport protein 2 inhibitors and the agonists of the glucagon-like peptide 1 receptor system, are reviewed. In summary, insights from ongoing research and the cardioprotective benefits of the newer type 2 diabetes therapies are providing novel areas for therapeutic opportunities in diabetes and CVD.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2EpidemicsSodium-Glucose Transporter 2 InhibitorsHumansHypoglycemic AgentsHypoglycemic AgentsSodium-Glucose Transporter 2 InhibitorsCardiovascular diseaseDiabetesEpigeneticsInterferon pathwaysMitochondrial dysfunctionTherapeutic agents

Identifiers

PMID34081211
PMCPMC8173334
OpenAlexW3165525015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.