Evidence map›Paper›PMID 34081176›Full record

ReviewOperative Orthopadie und Traumatologie2021

Prone-positioned knee arthroscopy for isolated retropatellar cartilage defects with gel-type autologous chondrocyte implantation.

Mahmut Enes Kayaalp, Yigit Umur Cirdi, Sebastian Kopf, Roland Becker

Abstract readReview
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In one paragraph

Review in Operative Orthopadie und Traumatologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Natural polymer-based scaffolds for soft tissue repair.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Mahmut Enes KayaalpDepartment of Orthopedics and Traumatology, Istanbul Taksim Training and Research Hospital, 34433, Istanbul, Turkey.
Yigit Umur CirdiDepartment of Orthopedics and Traumatology, Erciyes University School of Medicine, 38039, Kayseri, Turkey.
Sebastian KopfDepartment of Orthopedics and Traumatology, Hospital Brandenburg, Brandenburg Medical School "Theodor Fontane", Hochstraße 26, 14776, Brandenburg, Germany.
Roland BeckerDepartment of Orthopedics and Traumatology, Hospital Brandenburg, Brandenburg Medical School "Theodor Fontane", Hochstraße 26, 14776, Brandenburg, Germany. roland_becker@yahoo.de.
Klinikum Brandenburg · DEErciyes University · TRTaksim German Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTreatment of isolated retropatellar cartilage defects using current gel-type regenerative methods requires settlement of the gel to the underlying subchondral bone under gravity; thus, prone positioned arthroscopy is used. INDICATIONS: Isolated retropatellar contained cartilage defect size >2.5 cm CONTRAINDICATIONS: Cartilage defects at medial or lateral femorotibial compartments, at the trochlea, with degenerative genesis, rheumatoid arthritis, local infection, patellar malalignment, patellofemoral dysplasia, knee instability, knee malalignment >3°, kissing lesions. SURGICAL TECHNIQUE: Two-stage procedure: At initial arthroscopy, chondrocytes were harvested. At the second stage, the patient was positioned prone and the leg with a thigh tourniquet was fixed in a leg holder. Removal of table extension below the knee and support of foot in sling to prevent knee hyperextension. Placement of 2 lateral portals. Lesion visualized and debrided, followed by aspiration of intra-articular fluid. A loop, placed posterior to the patellar ligament using a lasso, was used to suspend a weight to expand the patellofemoral space. The lesion was then dried using a sponge. NOVOCART® Inject (TETEC, Reutlingen, Germany) administered onto the defect. Gel was allowed to solidify for 15 min and operation was completed. POSTOPERATIVE MANAGEMENT: Knee locked in extension using a brace for 6 weeks. Continuous passive motion applied and incrementally increased until full range of motion (ROM) at week 6. Weight-bearing as tolerated was allowed with the knee in extension. Routine clinical follow-up after 3, 6 and 12 months.

resultsMean age of the 5 patients was 23 ± 6 (range 14-30) years; mean follow-up time after surgery 28 ± 7 (range 20-40) months. All patients returned to full activity without residual knee ROM restriction. Clinical examination at the latest follow-up revealed a Kujala score of 90 ± 12 points and Lysholm score of 95 ± 5 points. MRI showed filled cartilage defects in all patients. Mocart score was 63 ± 7 points. Cartilage was inhomogeneous and hyperintense at the repaired site. Quantitative measurement of the patella mobility of the operated knee under a translating force of 10 N showed medial and lateral displacements of 21 ± 5 and 15 ± 2 mm and on the healthy side 22 ± 5 and 19 ± 3 mm, respectively.

Indexed as

ArthroscopyCartilage, ArticularAdultChild, PreschoolChondrocytesHumansInfantKnee JointTransplantation, AutologousTreatment OutcomeCollagenKnee jointMesenchymal stem cellsMinimally invasive surgical proceduresPatellar joint

Identifiers

PMID34081176
OpenAlexW3164908169

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.