Evidence map›Paper›PMID 34081158›Full record

ArticleAbdominal radiology (New York)2021

A radiomics-based nomogram for preoperative T staging prediction of rectal cancer.

Xue Lin, Sheng Zhao, Huijie Jiang, Fucang Jia, Guisheng Wang, Baochun He, Hao Jiang, Xiao Ma, Jinping Li, Zhongxing Shi

Abstract read
In one paragraph

Article in Abdominal radiology (New York), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  15. Technological Advancements in Interventional Oncology.Diagnostics (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xue LinDepartment of Radiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Sheng ZhaoDepartment of Radiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Huijie JiangDepartment of Radiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. jhjemail@163.com.ORCID http://orcid.org/0000-0002-8356-9643
Fucang JiaResearch Lab for Medical Imaging and Digital Surgery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. fc.jia@siat.ac.cn.
Guisheng WangDepartment of Radiology, the Third medical centre, Chinese PLA General Hospital, Beijing, China. wanggs1996@tom.com.
Baochun HeResearch Lab for Medical Imaging and Digital Surgery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Hao JiangDepartment of Radiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Xiao MaResearch Lab for Medical Imaging and Digital Surgery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Jinping LiDepartment of Radiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhongxing ShiDepartment of Interventional Radiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the value of a radiomics-based nomogram in predicting preoperative T staging of rectal cancer.

methodsA total of 268 eligible rectal cancer patients from August 2012 to December 2018 were enrolled and allocated into two datasets: training (n = 188) and validation datasets (n = 80). Another set of 32 patients from January 2019 to July 2019 was included in a prospective analysis. Pretreatment T2-weighted images were used to radiomics features extraction. Feature selection and radiomics score (Rad-score) construction were performed through a least absolute shrinkage and selection operator regression analysis. The nomogram, which included Rad-scores and clinical factors, was built using multivariate logistic regression. Discrimination, calibration, and clinical utility were used to evaluate the performance of the nomogram.

resultsThe Rad-score containing nine selected features was significantly related to T staging. Patients who had locally advanced rectal cancer (LARC) generally had higher Rad-scores than patients with early-stage rectal cancer. The nomogram incorporated Rad-scores and carcinoembryonic antigen levels and showed good discrimination, with an area under the curve (AUC) of 0.882 (95% confidence interval [CI] 0.835-0.930) in the training dataset and 0.846 (95% CI 0.757-0.936) in the validation dataset. The calibration curves confirmed high goodness of fit, and the decision curve analysis revealed the clinical value. A prospective analysis demonstrated that the AUC of the nomogram to predict LARC was 0.859 (95% CI 0.730-0.987).

conclusionA radiomics-based nomogram is a novel method for predicting LARC and can provide support in clinical decision making.

Indexed as

NomogramsRectal NeoplasmsHumansNeoplasm StagingRectumRetrospective StudiesMagnetic resonance imagingNomogramRectal cancerStaging

Identifiers

PMID34081158
PMCPMC8435521

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.