Evidence map›Paper›PMID 34081082›Full record

ArticleThe Journal of cell biology2021

Robustness and innovation along the endocytic route: Lessons from darkness.

Kaela S Singleton, Victor Faundez

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kaela S SingletonDepartment of Cell Biology, Emory University, Atlanta, GA.ORCID 0000-0003-2610-5890
Victor FaundezDepartment of Cell Biology, Emory University, Atlanta, GA.ORCID 0000-0002-2114-5271
Emory University · US

Funding

Neuronal Mechanisms of Copper Transport and ToxicityRF1AG060285 · NIA · EMORY UNIVERSITY · PI FAUNDEZ, VICTOR · 2018 to 2021
$2.4M
Integrity and localization of Mitochondria in Menkes Disease PathogenesisK00NS108539 · NINDS · EMORY UNIVERSITY · PI SINGLETON, KAELA S. · 2020 to 2023
$339k
NIA NIH HHS RF1 AG060285NINDS NIH HHS K00 NS108539NINDS NIH HHS L40 NS127400
6 · The paper itself

Abstract

What mechanisms ensure the loading of a SNARE into a nascent carrier? In this issue, Bowman et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202005173) describe an unprecedented mechanism where two sorting complexes, AP-3 and BLOC-1, the latter bound to syntaxin 13, work as a fail-safe to recognize sorting signals in VAMP7, a membrane protein required for fusion to melanosomes. Their observations define one of the first examples of distributed robustness in membrane traffic mechanisms.

Indexed as

MelanosomesSNARE ProteinsDarknessProtein TransportQa-SNARE ProteinsQa-SNARE ProteinsSNARE Proteins

Identifiers

PMID34081082
PMCPMC8178755
OpenAlexW3164769829

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.