Evidence map›Paper›PMID 34080888›Full record

ArticleFuture medicinal chemistry2021

Engineering 'Enzymelink' for screening lead compounds to inhibit mPGES-1 while maintaining prostacyclin synthase activity.

Diana T Ruan, Nanhong Tang, Hironari Akasaka, Renzhong Lu, Ke-He Ruan

Open access · greenAbstract read
In one paragraph

Article in Future medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Diana T RuanColumbia University Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-6339-8456
Nanhong TangThe Center for Experimental Therapeutics & Pharmacoinformatics, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.ORCID 0000-0001-7495-5254
Hironari AkasakaThe Center for Experimental Therapeutics & Pharmacoinformatics, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.ORCID 0000-0002-1077-7388
Renzhong LuThe Center for Experimental Therapeutics & Pharmacoinformatics, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.ORCID 0000-0002-5313-5967
Ke-He RuanThe Center for Experimental Therapeutics & Pharmacoinformatics, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.ORCID 0000-0001-7165-2231
University of Houston · USColumbia University · USFujian Medical University · CN

Funding

Prostaglandin I synthase, Thromboxane A synthase & Prostaglandin E synthaseR01HL056712 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI RUAN, KE-HE · 2000 to 2009
$2.3M
STRUCTURE &FUNCTION RELATIONSHIP: PROSTANOID RECEPTORSR01HL079389 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI RUAN, KE-HE · 2005 to 2008
$1.4M
NHLBI NIH HHS R01 HL056712NHLBI NIH HHS R01 HL079389
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Protein EngineeringBenzene DerivativesCyclooxygenase 1Cytochrome P-450 Enzyme SystemDrug Evaluation, PreclinicalHEK293 CellsHumansIntramolecular OxidoreductasesMicrosomesBenzene DerivativesCyclooxygenase 1Cytochrome P-450 Enzyme SystemIntramolecular Oxidoreductasesprostacyclin synthetasePTGS1 protein, humanCOX-2cyclooxygenase-2Enzymelinkinhibitorsmicrosomal prostaglandin E2 synthase-1mPGES-1PGISprostacyclin synthase

Identifiers

PMID34080888
PMCPMC8204920
OpenAlexW3165510416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.