Evidence map›Paper›PMID 34080666›Full record

ArticleOncology reports2021

Binding between ROCK1 and DCTN2 triggers diabetes‑associated centrosome amplification in colon cancer cells.

Yuan Fei Li, Lin Jie Shi, Pu Wang, Jia Wen Wang, Guang Yi Shi, Shao Chin Lee

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yuan Fei LiDepartment of Oncology, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
Lin Jie ShiDepartment of Oncology, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
Pu WangChangzhi Medical University, Changzhi, Shanxi 030001, P.R. China.
Jia Wen WangInstitute of Biomedical Sciences of The School of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu 221116, P.R. China.
Guang Yi ShiInstitute of Biomedical Sciences of The School of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu 221116, P.R. China.
Shao Chin LeeInstitute of Biomedical Sciences of The School of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu 221116, P.R. China.
Jiangsu Normal University · CNShanxi Medical University · CNChangzhi Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes increases the risk various types of cancer and is associated with a poor prognosis therein. There is also evidence that the disease is associated with cancer metastasis. Centrosome amplification can initiate tumorigenesis with metastasis

Indexed as

Cell Line, TumorCentrosomeColonic NeoplasmsDiabetes Mellitus, Type 2Dynactin ComplexGlucoseHCT116 CellsHumansInsulinModels, BiologicalPalmitic AcidProtein BindingProteomicsrho-Associated KinasesUp-RegulationDCTN2 protein, humanDynactin ComplexGlucoseInsulinPalmitic Acidrho-Associated KinasesROCK1 protein, humancentrosome amplificationcolon cancer cellsdynactin subunit 2functional proteomicsRho‑associated protein kinase 1type 2 diabetes

Identifiers

PMID34080666
PMCPMC8185503
OpenAlexW3164865966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.