Evidence map›Paper›PMID 34080650›Full record

ArticleMolecular medicine reports2021

Low‑calorie sweetener D‑psicose promotes hydrogen peroxide‑mediated apoptosis in C2C12 myogenic cells favoring skeletal muscle cell injury.

Zhen-Jie Wei, Lu Sun, Yu-Lin Li, Jibran Sualeh Muhammad, Ying Wang, Qian-Wen Feng, Yan-Zhuo Zhang, Hidekuni Inadera, Zheng-Guo Cui, Cheng-Ai Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. In Vitro Study on the Effects ofInternational journal of molecular sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhen-Jie Wei *Department of Molecular Orthopedics, Beijing Research Institute of Traumatology and Orthopedics, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.
Lu Sun *Department of Pediatric Cardiology, Heart Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, P.R. China.
Yu-Lin Li *Department of Public Health, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
Jibran Sualeh MuhammadDepartment of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
Ying WangDepartment of Molecular Orthopedics, Beijing Research Institute of Traumatology and Orthopedics, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.
Qian-Wen FengDepartment of Public Health, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
Yan-Zhuo ZhangDepartment of Molecular Orthopedics, Beijing Research Institute of Traumatology and Orthopedics, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.
Hidekuni InaderaDepartment of Public Health, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
Zheng-Guo CuiDepartment of Public Health, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
Cheng-Ai WuDepartment of Molecular Orthopedics, Beijing Research Institute of Traumatology and Orthopedics, Beijing Jishuitan Hospital, Beijing 100035, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diet and exercise are the most effective approaches used to induce weight loss. D‑psicose is a low‑calorie sweetener that has been shown to reduce weight in obese individuals. However, the effect of D‑psicose on muscle cells under oxidative stress, which is produced during exercise, requires further investigation. The present study aimed to determine the effects of D‑psicose on C2C12 myogenic cells in vitro. Hydrogen peroxide (H

Indexed as

AnimalsApoptosisCell ProliferationCell SurvivalFructoseHydrogen PeroxideMAP Kinase Signaling SystemMembrane Potential, MitochondrialMembrane ProteinsMiceM Phase Cell Cycle CheckpointsMuscle DevelopmentMuscle, SkeletalOxidative StressReactive Oxygen SpeciesSweetening AgentsFructoseHydrogen PeroxideMembrane ProteinspsicoseReactive Oxygen SpeciesSweetening AgentsapoptosisD‑psicoseMAPK signaling pathwaymuscle cellreactive oxygen species

Identifiers

PMID34080650
PMCPMC8170266

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.