Evidence map›Paper›PMID 34080581›Full record

ArticleFemale pelvic medicine & reconstructive surgery2021

Generic Health-Related Quality of Life in Patients Seeking Care for Pelvic Organ Prolapse.

Catherine S Bradley, Heidi W Brown, Stuart S Shippey, Robert E Gutman, Uduak U Andy, Ladin A Yurteri-Kaplan, Bela Kudish, Allen Mehr, Amy O'Boyle, Raymond T Foster and 4 more

Abstract readComparative Study
In one paragraph

Article in Female pelvic medicine & reconstructive surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Catherine S BradleyFrom the University of Iowa Carver College of Medicine, Iowa City, IA.
Heidi W BrownUniversity of Wisconsin School of Medicine and Public Health, Madison, WI.
Stuart S ShippeyRiverside Health System, Newport News, VA.
Robert E GutmanGeorgetown University/MedStar Washington Hospital Center, Washington, DC.
Uduak U AndyPerelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Ladin A Yurteri-KaplanColumbia University Irving Medical Center, New York, NY.
Bela KudishUniversity of Central Florida, Orlando, FL.
Allen MehrDepartment of Obstetrics and Gynecology, Tripler Army Medical Center, Honolulu, HI.
Amy O'BoyleProvidence Medical Group, Olympia, WA.
Raymond T FosterUniversity of Missouri School of Medicine, Columbia, MO.
Jennifer T AngerCedars-Sinai Medical Center, Los Angeles, CA.
Patrick Ten EyckUniversity of Iowa Institute for Clinical and Translational Science, Iowa City, IA.
Pamela A MoalliMagee Women's Hospital of the University of Pittsburgh, Magee Women's Research Institute, Pittsburgh, PA.
Developed by the Pelvic Floor Disorders Registry

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
Wisconsin Multidisciplinary K12 Urologic Research Career Development ProgramK12DK100022 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI CHAD M. VEZINA · 2013 to 2026
$8.6M
NCATS NIH HHS UL1 TR002373NCATS NIH HHS UL1 TR002537NIDDK NIH HHS K12 DK100022
6 · The paper itself

Abstract

objectiveUsing the American Urogynecologic Society multicenter Pelvic Floor Disorder Registry for Research, we (1) compared generic quality of life (QOL) in women planning pelvic organ prolapse (POP) treatment (surgery vs pessary), (2) correlated generic and condition-specific QOL scores, and (3) identified associations between generic QOL and other factors.

methodsThis cross-sectional analysis assessed generic physical and mental QOL using the Patient-Reported Outcomes Measurement Information System Global Health Scale at baseline. Global Physical and Mental T-scores center on a representative US population sample (mean [SD], 50 [10]; higher scores, better health). Condition-specific QOL was assessed with Pelvic Floor Distress Inventory, Pelvic Floor Impact Questionnaire, and POP/Urinary Incontinence Sexual Function Questionnaire. Linear regression models identified associations between clinical factors and Global Physical/Mental scores.

resultsFive hundred sixty-eight women (419 surgery, 149 pessary) were included. Surgery patients were younger, heavier, and more often sexually active (all P's ≤ 0.01). Global Physical scores were lower in the surgery versus pessary group, but not likely clinically meaningful (mean [SD], 48.8 [8.1] vs 50.4 [8.5]; P = 0.035); Global Mental scores were similar (51.4 [8.4] vs 51.9 [9.5], P = 0.56). Global Health scores correlated with Pelvic Floor Distress Inventory, Pelvic Floor Impact Questionnaire, and POP/Urinary Incontinence Sexual Function Questionnaire scores (all P's < 0.0001). In multivariable models, menopause was associated with better physical QOL, and constipation, coronary artery disease, pelvic pain, and increased body mass index with worse physical QOL. Age was associated with better mental QOL, and constipation, fecal incontinence, pelvic pain, and coronary artery disease with worse mental QOL.

conclusionsWomen choosing POP surgery versus pessary had similar physical and mental generic QOL.

Indexed as

Quality of LifeAgedCross-Sectional StudiesFemaleGynecologic Surgical ProceduresHumansMiddle AgedPelvic Organ ProlapsePessariesUrologic Surgical Procedures

Identifiers

PMID34080581
PMCPMC9039983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.