Evidence map›Paper›PMID 34080496›Full record

ArticleAnnals of medicine2021

Risk factors for major adverse cardiovascular events after the first acute coronary syndrome.

Marjo Okkonen, Aki S Havulinna, Olavi Ukkola, Heikki Huikuri, Arto Pietilä, Heli Koukkunen, Seppo Lehto, Juha Mustonen, Matti Ketonen, Juhani Airaksinen and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Annals of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07032389 (Polypill Strategy for the Treatment of Patients After Acute Coronary Syndromes - A Multicenter Randomized Controlled Trial), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07032389 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Polypill Strategy for the Treatment of Patients After Acute Coronary Syndromes - A Multicenter Randomized Controlled Trial

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2025 to 2030Enrolled1,000ConditionsAcute Coronary SyndromeArmsPolypill
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
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  4. Longitudinal Psychosocial and Sleep Assessments for Long-Term Cardiovascular Risk Stratification after First Myocardial Infarction in Rural India.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026
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  5. Observational
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  13. Long-term all-cause mortality rate after ST-elevation myocardial infarction and its predictors: ST Elevation Myocardial Infarction Cohort in Isfahan Study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
    Article
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  16. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Marjo OkkonenResearch Unit of Internal Medicine, University of Oulu, Oulu, Finland.
Aki S HavulinnaFinnish Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0002-4787-8959
Olavi UkkolaResearch Unit of Internal Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0001-7414-2608
Heikki HuikuriResearch Unit of Internal Medicine, University of Oulu, Oulu, Finland.
Arto PietiläFinnish Institute for Health and Welfare, Helsinki, Finland.
Heli KoukkunenKuopio University Hospital, Kuopio, Finland.ORCID 0000-0001-6650-8075
Seppo LehtoUniversity of Eastern Finland, Kuopio, Finland.
Juha MustonenNorth Karelia Central Hospital, Joensuu, Finland.
Matti KetonenNorth Karelia Central Hospital, Joensuu, Finland.
Juhani AiraksinenUniversity of Turku and Heart Center Turku University Hospital, Turku, Finland.ORCID 0000-0002-0193-568X
Y Antero KesäniemiResearch Unit of Internal Medicine, University of Oulu, Oulu, Finland.
Veikko SalomaaFinnish Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0001-7563-5324
Oulu University Hospital · FIFinnish Institute for Health and Welfare · FINorth Karelia Central Hospital · FIUniversity of Eastern Finland · FIUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo evaluate risk factors for major adverse cardiac event (MACE) after the first acute coronary syndrome (ACS) and to examine the prevalence of risk factors in post-ACS patients.

methodsWe used Finnish population-based myocardial infarction register, FINAMI, data from years 1993-2011 to identify survivors of first ACS (

resultsOf the first ACS survivors, 48.4% had MACE within three years of their primary event, 17.0% were fatal. Diabetes (p = 4.4 × 10

conclusionDiabetes, higher Charlson index and HF are the most important risk factors of MACE after the first ACS. Cardiovascular risk factor levels were still high among survivors of first ACS.

Indexed as

Acute Coronary SyndromeDiabetes MellitusHeart FailureMyocardial InfarctionAgedHumansRisk AssessmentRisk Factorsacute coronary syndromesEpidemiologymajor adverse cardiac eventprevention

Identifiers

PMID34080496
PMCPMC8183550
OpenAlexW3165695679

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.