Evidence map›Paper›PMID 34080169›Full record

ArticleInternational journal of hematology2021

Reference intervals of red blood cell parameters and platelet count for healthy adults in Japan.

Akiyoshi Takami, Shinichiro Watanabe, Yoshikazu Yamamoto, Hiroshi Kondo, Yukiharu Bamba, Masahiko Ohata, Seiji Mishima, Hiroshi Kubota, Akihiko Nishiura, Reiko Miura and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Mean Corpuscular Volume inJournal of hematology · 2026
    Article
  5. Article
  6. Article
  7. Observational
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Akiyoshi TakamiDivision of Hematology, Department of Internal Medicine, School of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, 480-1195, Japan. takami-knz@umin.ac.jp.ORCID http://orcid.org/0000-0002-1822-9976
Shinichiro WatanabeFujisawa City Hospital, Fujisawa, Japan.
Yoshikazu YamamotoTenri Health Care University, Tenri, Japan.
Hiroshi KondoKansai University of Health Sciences, Kumatori, Japan.
Yukiharu BambaBML General Laboratory, BML, INC, Kawagoe, Japan.
Masahiko OhataShizuoka Red Cross Hospital, Shizuoka, Japan.
Seiji MishimaSanyo women's college, Hatsukaichi, Japan.
Hiroshi KubotaClinical Laboratory, Osaka City University Hospital, Osaka, Japan.
Akihiko NishiuraKyushu Medical Center, National Hospital Organization, Fukuoka, Japan.
Reiko MiuraSapporo Hokuyu Hospital, Sapporo, Japan.
Miyuki IwagamiTatebayashi Kosei General Hospital, Tatebayashi, Japan.
Katsumi HigashiKyorin University School of Health Sciences, Kyorin, Japan.
Yutaka YatomiDepartment of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kaoru TohyamaKawasaki Medical School Hospital, Kurashiki, Japan.
Japanese Society for Laboratory Hematology Standardization Committee (JSLH-SC) and Joint Working Group of the JSLH and the Japanese Association of Medical Technologists (JWG-JSLH-JAMT).

Funding

Ministry of Education, Culture, Sports and Technology of Japan #18K08343
6 · The paper itself

Abstract

Although it is known that red blood cell (RBC) parameters and platelet count depend on ethnicity and sex, their reference intervals in healthy Asian populations are limited. The aim of this study was to establish reference intervals for RBC parameters and platelet count for healthy adults in Japan. A total of 750 healthy adults (447 women and 303 men; median age 40 years (18-67 years) at seven Japanese centers who participated in regular medical checkups entered this study. Their RBC parameters and platelet count were measured using automated hematocytometers. The reference intervals of the RBC parameters and platelet count according to sex in healthy adults were determined. There was an age-specific decrease in RBC counts and an age-specific increase in mean corpuscular volume in men. This study emphasizes the need to consider sex and age in the clinical use of reference intervals of RBC parameters.

Indexed as

BiomarkersErythrocyte IndicesPlatelet CountAdolescentAdultAgedFemaleHealthy VolunteersHumansJapanMaleMiddle AgedPublic Health SurveillanceYoung AdultBiomarkersMean corpuscular volumePlatelet countRed blood cell parametersReference interval

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.