Evidence map›Paper›PMID 34080056›Full record

ArticleInternational journal of implant dentistry2021

Pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy.

Karsten Kern, Fania Lukmann, Karina Obreja, Sara Al-Maawi, Bellinghausen Carla, Shahram Ghanaati, Gernot Rohde, Robert Sader, Frank Schwarz

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In one paragraph

Article in International journal of implant dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Karsten KernDepartment of Oral Surgery and Implantology, Goethe University, Carolinum, Frankfurt, Germany.
Fania LukmannDepartment of Oral Surgery and Implantology, Goethe University, Carolinum, Frankfurt, Germany.
Karina ObrejaDepartment of Oral Surgery and Implantology, Goethe University, Carolinum, Frankfurt, Germany.
Sara Al-MaawiDepartment for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt, Germany.
Bellinghausen CarlaDepartment of Respiratory Medicine and Allergology, University Hospital, Goethe University, Frankfurt, Germany.
Shahram GhanaatiDepartment for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt, Germany.
Gernot RohdeDepartment of Respiratory Medicine and Allergology, University Hospital, Goethe University, Frankfurt, Germany.
Robert SaderDepartment for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt, Germany.
Frank SchwarzDepartment of Oral Surgery and Implantology, Goethe University, Carolinum, Frankfurt, Germany. f.schwarz@med.uni-frankfurt.de.ORCID 0000-0002-5873-9903
Goethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the influence of antiresorptive/antiangiogenic therapy on the spreading of peri-implant infections in the pharyngeal region. MATERIAL AND

methodsThis analysis was based on tissue biopsies obtained from a total of twenty-five albino rats having either received (1) amino-bisphosphonate (Zoledronate) (Zo) (n=4), (2) RANKL inhibitor (Denosumab) (De) (n=4), (3) antiangiogenic medication (Bevacizumab) (Be) (n=4), (4) Zo+Be (n=3), (5) De+Be (n=5), or (6) no medication (Co) (n=5). Drug administration was repeated at 12 weeks. Chronic-type peri-implant infections were induced at titanium implants located in the upper jaws. The surface area (%) of infiltrated connective tissue (ICT) and CD68-positive cells was assessed within the lateral pharyngeal/retropharyngeal connective tissue zone.

resultsMean (±SD) and median ICT% values and CD68 counts were markedly highest in the De+Be (11.10±6.04; 11.81; 95% CI - 3.89; 26.11) and De (5.70±5.06; 6.19; 95% CI - 2.34; 13.75) groups, reaching statistical significance for De CD68 counts over the Co (0.18±0.25; 0.18; 95% CI -2.14; 2.51) group. In both De+Be and De groups, the ICTs were occasionally associated with an ulceration of the epithelial compartment.

conclusionsInduced peri-implant infections were not associated with any inflammatory lesions in pharyngeal tissues. While these findings were similar under Zo and Be medication, De and De+Be had a marked effect on ICT and CD68 values. The clinical relevance of these adverse findings needs further investigation.

Indexed as

Bone Density Conservation AgentsDiphosphonatesAnimalsConnective TissueRatsTitaniumBone Density Conservation AgentsDiphosphonatesTitaniumAnimal experimentAntiresorptive/antiangiogenic therapyCD68 antigenImmunohistochemistryPeri-implant infections

Identifiers

PMID34080056
PMCPMC8172650
OpenAlexW3164804367

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.