ArticleNature cancer2020
The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome.
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Article in Nature cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
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Who cites it
62 citing papers in PubMed, 102 citations in OpenAlex.
- Recurrent mechanisms of biallelic epigenetic inactivation reveal new putative tumour suppressor genes in prostate cancer.Nature communications · 2026Article
- Integrated multiomic profiling reveals 2 distinct splenic marginal zone lymphoma subgroups with prognostic relevance.Blood advances · 2026Article
- DNA methylation-based classification of hematolymphoid neoplasms.Blood advances · 2026Article
- Clinical utility of sarcoma methylation classifiers in soft tissue sarcoma diagnosis.Journal of cancer research and clinical oncology · 2026Article
- Chronic lymphocytic leukemia withHemaSphere · 2026Article
- An integrative molecular map of pediatric B-cell precursor acute lymphoblastic leukemia.Communications medicine · 2026Article
- DNA methylation profiles aid to identify putative genome activation histories along lymphomagenesis.NAR genomics and bioinformatics · 2026Article
- Tumour-based epigenetic signatures as markers of prostate cancer aggressiveness after radical prostatectomy.British journal of cancer · 2026Article
- Deconvolution of haematological cancer methylation patterns reveals a predominantly non-disease related proliferation signal and uncovers true disease associated methylation changes.British journal of cancer · 2026Article
- Identification of two epitypes of IGHV unmutated chronic lymphocytic leukemia with distinct B-cell-related epigenetic imprinting and genetic alterations.HemaSphere · 2026Article
- Analysis of Chromatin Structure Using Network Approaches: A Step-by-Step Guide.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Microglial Replacement Reverses Age-Associated Epigenetic Modifications Despite Accelerating Epigenetic Age.Aging and disease · 2025Article
- The Chronic Lymphocytic Leukemia Epigenome: A Powerful and Stable Framework for Understanding Biological and Clinical Heterogeneity.Hematology/oncology clinics of North America · 2025Review
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- Direct genetic transformation bypasses tumor-associated DNA methylation alterations.Genome biology · 2025Article
- DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features.Blood cancer discovery · 2025Article
- Celebrating Ulrik Ringborg: Multi-Omics-Based Patient Stratification for Precision Cancer Treatment.Biomolecules · 2025Review
- Article
- Epigenetic ageing clocks: statistical methods and emerging computational challenges.Nature reviews. Genetics · 2025Review
- Subgrouping germinal center-derived B-cell lymphomas based on machine learning-deduced DNA methylation modules.Leukemia · 2025Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
32 authors at 13 institutions in 6 countries.
Martí Duran-FerrerInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. maduran@clinic.cat.ORCID http://orcid.org/0000-0003-1666-5819
Guillem ClotInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Ferran NadeuInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID http://orcid.org/0000-0003-2910-9440
Renée BeekmanInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Tycho BaumannCentro de Investigación Biomédica en Red de Cáncer, CIBERONC, Madrid, Spain.
Jessica NordlundDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Yanara Marincevic-ZunigaDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Gudmar LönnerholmDepartment of Women's and Children's Health, Pediatrics, Uppsala University, Uppsala, Sweden.
Alfredo Rivas-DelgadoInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID http://orcid.org/0000-0003-0385-3415
Silvia MartínInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Raquel OrdoñezCentro de Investigación Biomédica en Red de Cáncer, CIBERONC, Madrid, Spain.
Giancarlo CastellanoInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Marta KulisInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Ana C QueirósInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Seung-Tae LeeDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
Joseph WiemelsCenter for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
Romina RoyoPrograma Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain.
Montserrat PuiggrósPrograma Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-5034-7924
Junyan LuEuropean Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Eva GinéInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Sílvia BeàInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Pedro JaresInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID http://orcid.org/0000-0002-8401-579X
Xabier AgirreCentro de Investigación Biomédica en Red de Cáncer, CIBERONC, Madrid, Spain.ORCID http://orcid.org/0000-0002-6558-9560
Felipe ProsperCentro de Investigación Biomédica en Red de Cáncer, CIBERONC, Madrid, Spain.
Carlos López-OtínCentro de Investigación Biomédica en Red de Cáncer, CIBERONC, Madrid, Spain.ORCID http://orcid.org/0000-0001-6964-1904
Xosé S PuenteCentro de Investigación Biomédica en Red de Cáncer, CIBERONC, Madrid, Spain.ORCID http://orcid.org/0000-0001-9525-1483
Christopher C OakesDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Thorsten ZenzDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-7890-9845
Julio DelgadoInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Armando López-GuillermoInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Elías CampoInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID http://orcid.org/0000-0001-9850-9793
José Ignacio Martín-SuberoInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. imartins@clinic.cat.ORCID http://orcid.org/0000-0001-8809-5195
Centro de Investigación Biomédica en Red de Cáncer · ESHospital Clínic de Barcelona · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESUppsala University · SEBarcelona Supercomputing Center · ESUniversidad de Oviedo · ESClinica Universidad de Navarra · ESEuropean Molecular Biology Laboratory · DEInstitució Catalana de Recerca i Estudis Avançats · ESThe Ohio State University · USUniversity Hospital of Zurich · CHUniversity of Southern California · USYonsei University · KR
Funding
Preclinical Models and Therapeutics CoreP01CA229100 · NCI · MAYO CLINIC ARIZONA · PI SCOTT, DAVID WILLIAM · 2018 to 2022
$10.2MNCI NIH HHS P01 CA229100
Abstract
We report a systematic analysis of the DNA methylation variability in 1,595 samples of normal cell subpopulations and 14 tumor subtypes spanning the entire human B-cell lineage. Differential methylation among tumor entities relates to differences in cellular origin and to
Indexed as
EpigenomeNeoplasmsDNA MethylationEpigenesis, GeneticGene Expression Regulation, NeoplasticHumans
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