Evidence map›Paper›PMID 34079897›Full record

ArticleACS central science2021

Chemiluminescent Protease Probe for Rapid, Sensitive, and Inexpensive Detection of Live

Brett M Babin, Gabriela Fernandez-Cuervo, Jessica Sheng, Ori Green, Alvaro A Ordonez, Mitchell L Turner, Laura J Keller, Sanjay K Jain, Doron Shabat, Matthew Bogyo

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
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  4. Chemiluminescent probes for imaging cysteine cathepsin activity.Bioorganic & medicinal chemistry letters · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Brett M BabinDepartment of Pathology, Stanford University School of Medicine, Stanford, California 94305, United States.
Gabriela Fernandez-CuervoDepartment of Pathology, Stanford University School of Medicine, Stanford, California 94305, United States.
Jessica ShengDepartment of Pathology, Stanford University School of Medicine, Stanford, California 94305, United States.
Ori GreenSchool of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Alvaro A OrdonezCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.ORCID 0000-0002-8571-0655
Mitchell L TurnerCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.
Laura J KellerDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, United States.
Sanjay K JainCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States.ORCID 0000-0001-9620-7070
Doron ShabatSchool of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Matthew BogyoDepartment of Pathology, Stanford University School of Medicine, Stanford, California 94305, United States.ORCID 0000-0003-3753-4412
Stanford University · USJohns Hopkins University · USTel Aviv University · IL

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
MOLECULAR BASIS OF HOST-PARASITE INTERACTIONT32AI007328 · NIAID · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 1987 to 2026
$11.9M
Staphylococcus serine hydrolases as targets for therapeutic and imaging contrast agentsR01EB026332 · NIBIB · STANFORD UNIVERSITY · PI BOGYO, MATTHEW · 2018 to 2021
$1.4M
Measuring Intralesional Bedaquiline Exposures in Cavitary TB Using Noninvasive In Vivo PET ImagingR21AI149760 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY, ORDONEZ, ALVARO ANDRES · 2020 to 2021
$450k
NCATS NIH HHS UL1 TR003142NIAID NIH HHS R21 AI149760NIAID NIH HHS T32 AI007328NIBIB NIH HHS R01 EB026332
6 · The paper itself

Abstract

Tuberculosis (TB) is a top-ten cause of death worldwide. Successful treatment is often limited by insufficient diagnostic capabilities, especially at the point of care in low-resource settings. The ideal diagnostic must be fast, be cheap, and require minimal clinical resources while providing high sensitivity, selectivity, and the ability to differentiate live from dead bacteria. We describe here the development of a fast, luminescent, and affordable sensor of Hip1 (FLASH) for detecting and monitoring drug susceptibility of

Identifiers

PMID34079897
PMCPMC8161474
OpenAlexW3155064178

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.