Evidence map›Paper›PMID 34079817›Full record

ReviewFrontiers in molecular biosciences2021

Alternative Animal Models of Aging Research.

Susanne Holtze, Ekaterina Gorshkova, Stan Braude, Alessandro Cellerino, Philip Dammann, Thomas B Hildebrandt, Andreas Hoeflich, Steve Hoffmann, Philipp Koch, Eva Terzibasi Tozzini and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 2 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
  2. Impact of aging on animal models of Parkinson's disease.Frontiers in aging neuroscience · 2022
    Pooled it
  3. Review
  4. A comprehensive embryonic staging series of the turtle Trachemys scripta.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  5. Modeling versatility as the hallmark of model organisms.History and philosophy of the life sciences · 2026
    Article
  6. Article
  7. Review
  8. Viability ofmicroPublication biology · 2026
    Article
  9. Article
  10. Effects of SRWFood & nutrition research · 2026
    Article
  11. Article
  12. Microvascular Health as a Key Determinant of Organismal Aging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Germ cells and the aging niche: a systems approach to reproductive longevity.Journal of assisted reproduction and genetics · 2025
    Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 4 countries.

Susanne HoltzeDepartment of Reproduction Management, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany.
Ekaterina GorshkovaCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Stan BraudeDepartment of Biology, Washington University in St. Louis, St. Louis, MO, United States.
Alessandro CellerinoBiology Laboratory, Scuola Normale Superiore, Pisa, Italy.
Philip DammannDepartment of General Zoology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.
Thomas B HildebrandtDepartment of Reproduction Management, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany.
Andreas HoeflichDivision Signal Transduction, Institute for Genome Biology, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany.
Steve HoffmannComputational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany.
Philipp KochCore Facility Life Science Computing, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany.
Eva Terzibasi TozziniDepartment of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy.
Maxim SkulachevBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Vladimir P SkulachevBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Arne SahmComputational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany.
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DELomonosov Moscow State University · RULeibniz Institute for Zoo and Wildlife Research · DEResearch Institute for Farm Animal Biology (FBN) · DEScuola Normale Superiore · ITStazione Zoologica Anton Dohrn · ITUniversity of Duisburg-Essen · DEWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most research on mechanisms of aging is being conducted in a very limited number of classical model species, i.e., laboratory mouse (

Indexed as

Greenland sharkHeterocephalus glaberHydra oligactisMyotisNothobranchius furzeriProteus anguinusresistance to cancerSenescence

Identifiers

PMID34079817
PMCPMC8166319
OpenAlexW3160025918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.