Evidence map›Paper›PMID 34079705›Full record

ArticleQuantitative imaging in medicine and surgery2021

Feasibility of dual-phase

Yasser G Abdelhafez, Felipe Godinez, Kanika Sood, Rosalie J Hagge, Robert D Boutin, Siba P Raychaudhuri, Ramsey D Badawi, Abhijit J Chaudhari

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Imaging of Synovial Inflammation in Osteoarthritis, From theAJR. American journal of roentgenology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Yasser G AbdelhafezDepartment of Radiology, University of California Davis, Sacramento, CA, USA.
Felipe GodinezDepartment of Radiology, University of California Davis, Sacramento, CA, USA.
Kanika SoodRheumatology Section, Sacramento Veterans Affairs Medical Center, Mather, CA, USA.
Rosalie J HaggeDepartment of Radiology, University of California Davis, Sacramento, CA, USA.
Robert D BoutinDepartment of Radiology, University of California Davis, Sacramento, CA, USA.
Siba P RaychaudhuriRheumatology Section, Sacramento Veterans Affairs Medical Center, Mather, CA, USA.
Ramsey D BadawiDepartment of Radiology, University of California Davis, Sacramento, CA, USA.
Abhijit J ChaudhariDepartment of Radiology, University of California Davis, Sacramento, CA, USA.
University of California, Davis · USAssiut University · EGKing's College London · GBStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo prospectively demonstrate the feasibility of performing dual-phase SPECT/CT for the assessment of the small joints of the hands of rheumatoid arthritis (RA) patients, and to evaluate the reliability of the quantitative and qualitative measures derived from the resulting images.

methodsA SPECT/CT imaging protocol was developed in this pilot study to scan both hands simultaneously in participants with RA, in two phases of

resultsFour participants completed seven studies (all four were imaged at baseline, and three of them at follow-up after 1-month of arthritis therapy). A total of 280 joints (20 per hand) were evaluated. The MCCR from soft-tissue phase scans was significantly higher for clinically abnormal joints compared to clinically normal ones; P<0.001, however the MCCR from the osseous phase scans were not different between the two joint groups. Intraclass Correlation Coefficient (ICC) for MCCR was excellent [0.9789, 95% confidence interval (CI): 0.9734-0.9833]. Intra-observer agreement for qualitative SPECT findings was substantial for both the soft-tissue phase (kappa =0.78, 95% CI: 0.72-0.83) and osseous-phase (kappa =0.70, 95% CI: 0.64-0.76) scans.

conclusionsExtracting reliable quantitative and qualitative measures from dual-phase 99mTc-MDP SPECT/CT hand scans is feasible in RA patients. SPECT/CT may provide a unique means for assessing both synovitis and osseous involvement in RA joints using the same radiotracer injection.

Indexed as

Bone scanosteoblastic responserheumatoid arthritissoft tissue vascularitySPECT/CT

Identifiers

PMID34079705
PMCPMC8107345
OpenAlexW3155557349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.