Evidence map›Paper›PMID 34079702›Full record

ArticleQuantitative imaging in medicine and surgery2021

Computer-assisted ultrasound assessment of plaque characteristics in radiation-induced and non-radiation-induced carotid atherosclerosis.

Yuanxi Li, Dora Lai-Wan Kwong, Vincent Wing-Cheung Wu, Shea-Ping Yip, Helen Ka-Wai Law, Shara Wee-Yee Lee, Michael Tin-Cheung Ying

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05706168 (A Study to Investigate the Effects of Aerobic Exercise Training), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05706168 naunknown statusnot on this mapstarted 2023, after this paper: background citation

A Study to Investigate the Effects of Aerobic Exercise Training (AET) on the Large Intracranial and Extracranial Cerebral Arteries and the Cognitive and Motor Functions in Post Stroke Patients.

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2023 to 2024Enrolled120ConditionsStrokeArmstreadmill exercise, Cycle ergometer exercise
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Stroke in Asia.Cerebrovascular diseases extra · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yuanxi LiDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Dora Lai-Wan KwongDepartment of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
Vincent Wing-Cheung WuDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Shea-Ping YipDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Helen Ka-Wai LawDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Shara Wee-Yee LeeDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Michael Tin-Cheung YingDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Hong Kong Polytechnic University · HKUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study investigated the feasibility of using a computer-assisted method to evaluate and differentiate the carotid plaque characteristics in radiation-induced and non-radiation-induced carotid atherosclerosis.

methodsThis study included 107 post-radiotherapy (post-RT) nasopharyngeal carcinoma (NPC) patients and 110 subjects with cardiovascular risk factors (CVRFs). Each participant had a carotid ultrasound examination, and carotid plaques and carotid intima-media thickness (CIMT) were evaluated with grey scale ultrasound. The carotid plaque characteristics were evaluated for grey-scale median (GSM) and detailed plaque texture analysis (DPTA) using specific computer software. In DPTA, five different intra-plaque components were colour-coded according to different grey scale ranges. A multivariate linear regression model was used to evaluate the correlation of risk factors and carotid plaque characteristics.

resultsPost-RT NPC patients have significantly higher CIMT (748±15.1 µm, P=0.001), more patients had a plaque formation (80.4%, P<0.001) and more plaque locations (2.3±0.2, P<0.001) than CVRF subjects (680.4±10.0 µm, 38.2% and 0.5±0.1 respectively). Among the five intra-plaque components, radiation-induced carotid plaques had significantly larger area of calcification (4.8%±7.7%, P=0.012), but lesser area of lipid (42.1%±16.9%, P=0.034) when compared to non-radiation-induced carotid plaques (3.0%±5.7% and 46.3%±17.9% respectively). Age, radiation and number of CVRF were significantly associated with the carotid atherosclerosis burden (P<0.001). Besides, age was significantly associated with the amount of lipid and calcification within carotid plaques (P<0.001).

conclusionsRadiation caused more severe carotid artery disease than CVRF with larger CIMT and more prevalent of carotid plaque. Radiation-induced carotid plaques tended to have more intra-plaque calcifications, whereas non-radiation-induced carotid plaques had more lipids. Ultrasound aided by computer-assisted image analysis has potential for more accurate assessment of carotid atherosclerosis.

Indexed as

Atherosclerotic plaquecarotid atherosclerosisradiation effectsultrasound

Identifiers

PMID34079702
PMCPMC8107311
OpenAlexW3138561122

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.