Evidence map›Paper›PMID 34079627›Full record

ArticleAmerican journal of blood research2021

Lower hair cortisol among patients with sickle cell disease may indicate decreased adrenal reserves.

Brittany M Hollister, Mihail Zilbermint, Caterina P Minniti, Ashley J Buscetta, Khadijah E Abdallah, Shuo You, Steven J Soldin, Jerrold S Meyer, Constantine A Stratakis, Vence L Bonham

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of blood research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Endocrinopathies in Hemoglobinopathies: What Is the Role of Iron?International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Brittany M HollisterSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health Bethesda, Maryland, USA.
Mihail ZilbermintSection on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health Bethesda, Maryland, USA.
Caterina P MinnitiDivision of Hematology, Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine New York, New York, USA.
Ashley J BuscettaSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health Bethesda, Maryland, USA.
Khadijah E AbdallahSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health Bethesda, Maryland, USA.
Shuo YouDivision of Hematology, Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine New York, New York, USA.
Steven J SoldinDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health Bethesda, Maryland, USA.
Jerrold S MeyerDepartment of Psychological and Brain Sciences, University of Massachusetts Amherst, Massachusetts, USA.
Constantine A StratakisSection on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health Bethesda, Maryland, USA.
Vence L BonhamSocial and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health Bethesda, Maryland, USA.
National Institutes of Health · USNational Human Genome Research Institute · USNational Institutes of Health Clinical Center · USUniversity of Massachusetts Amherst · US

Funding

Molecular Genetics of Endocrine Tumors and Related DisordersZIAHD008920 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATAKIS, CONSTANTINE A. · 2012 to 2021
$25.8M
Insights into Sickle Cell Trait and Sickle Cell DiseaseZIAHG200394 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BONHAM, VENCE L · 2014 to 2025
$3.8M
Intramural NIH HHS ZIA HG200394
6 · The paper itself

Abstract

introductionSickle cell disease (SCD) is a chronic illness that presents with a wide range of phenotypic variation. Stress may be a contributing factor to differences that are found in this population.

objectivesOur objective is to determine the relationship between hair cortisol content (HCC), a biomarker of stress, and other clinical measures in individuals with SCD.

methodsWe collected hair samples and other clinical measures from 73 subjects with SCD (mean age: 39 ± 12 years, 63% female).

resultsHCC was lower among individuals who had greater than 30% hemoglobin S, compared with those who had less than 30% hemoglobin S (W=272.5, P=0.01). Lower HCC was also associated with report of not being on a chronic transfusion program (β=48.34, SE=14.09, P=0.001) and higher ferritin levels (β=-0.006, SE=0.002, P=0.02). Furthermore, HCC was significantly correlated with serum cortisol (r

conclusionOur findings suggest that individuals with higher hemoglobin S and ferritin, both markers of severe SCD, may have decreased cortisol levels. This is consistent with the relationship we observed between higher HCC among individuals who are on a chronic blood transfusion program, which typically increases quality of life. Our results suggest that hair cortisol may be an indicator in patients with SCD who could be at risk for developing adrenal insufficiency. We recommend that clinicians treating patients with SCD follow the Endocrine Society guidelines for testing for adrenal insufficiency and treat accordingly.

Indexed as

corticosteroidssickle cell anemiaSickle cell diseasesteroids

Identifiers

PMID34079627
PMCPMC8165714
OpenAlexW3165107462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.