Evidence map›Paper›PMID 34079553›Full record

ArticleFrontiers in immunology2021

Amelioration of Beta Interferon Inhibition by NS4B Contributes to Attenuating Tembusu Virus Virulence in Ducks.

Wei Zhang, Miao Zeng, Bowen Jiang, Tong Lu, Jiaqi Guo, Tao Hu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Wei ZhangResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Miao ZengResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Bowen JiangResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Tong LuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Jiaqi GuoResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Tao HuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Mingshu WangResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Renyong JiaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Dekang ZhuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Mafeng LiuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Xinxin ZhaoResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Qiao YangResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Ying WuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Shaqiu ZhangResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Xumin OuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Yunya LiuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Ling ZhangResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Yanling YuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Leichang PanResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Anchun ChengResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.
Shun ChenResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous studies reported that duck Tembusu virus nonstructural protein 2A (NS2A) is a major inhibitor of the IFNβ signaling pathway through competitively binding to STING with TBK1, leading to a reduction in TBK1 phosphorylation. Duck TMUV NS2B3 could cleave and bind STING to subvert the IFNβ signaling pathway. Here, we found that overexpression of duck TMUV NS4B could compete with TBK1 in binding to STING, reducing TBK1 phosphorylation and inhibiting the IFNβ signaling pathway by using the Dual-Glo

Indexed as

AnimalsBird DiseasesDucksFlavivirusFlavivirus InfectionsInterferon-betaViral Nonstructural ProteinsVirulenceInterferon-betaNS4B protein, flavivirusViral Nonstructural Proteinsbeta interferonduck TMUV NS4Bimmune evasionSTINGvirus replication

Identifiers

PMID34079553
PMCPMC8165282

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.