Evidence map›Paper›PMID 34079550›Full record

ArticleFrontiers in immunology2021

Comparative Analysis on Abnormal Methylome of Differentially Expressed Genes and Disease Pathways in the Immune Cells of RA and SLE.

Qinghua Fang, Tingyue Li, Peiya Chen, Yuzhe Wu, Tingting Wang, Lixia Mo, Jiaxin Ou, Kutty Selva Nandakumar

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Hypomethylation of the HumanArchives of Iranian medicine · 2026
    Article
  3. Article
  4. Review
  5. NF-κB in inflammation and cancer.Cellular & molecular immunology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases.Clinical reviews in allergy & immunology · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Qinghua FangSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Tingyue LiLaboratory of Experimental Oncology, Department of Pathology, Erasmus Medical Center, Rotterdam, Netherlands.
Peiya ChenDepartment of Science and Education, First Affiliated Hospital of Jinan University, Guangzhou, China.
Yuzhe WuSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Tingting WangSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Lixia MoSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Jiaxin OuSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Kutty Selva NandakumarSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Southern Medical University · CNErasmus MC · NLFirst Affiliated Hospital of Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We identified abnormally methylated, differentially expressed genes (DEGs) and pathogenic mechanisms in different immune cells of RA and SLE by comprehensive bioinformatics analysis. Six microarray data sets of each immune cell (CD19

Indexed as

EpigenomeEpigenomicsSite-Specific DNA-Methyltransferase (Adenine-Specific)Arthritis, RheumatoidAutoantibodiesDatabases, GeneticGene Regulatory NetworksHumansLupus Erythematosus, SystemicOligonucleotide Array Sequence AnalysisProtein Interaction MapsSignal TransductionAutoantibodiesDNA modification methylase CcrMSite-Specific DNA-Methyltransferase (Adenine-Specific)bioinformatics analysisimmune cellsmethylationrheumatoid arthritissystemic lupus erythematosus

Identifiers

PMID34079550
PMCPMC8165287
OpenAlexW3163871450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.