Evidence map›Paper›PMID 34079548›Full record

ArticleFrontiers in immunology2021

The Role of Inflammation and Immune Activation on Circulating Endothelial Progenitor Cells in Chronic HIV Infection.

Ziang Zhu, Tong Li, Jinya Chen, Jai Kumar, Princy Kumar, Jing Qin, Colleen Hadigan, Irini Sereti, Jason V Baker, Marta Catalfamo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ziang ZhuDepartment of Microbiology and Immunology. Georgetown University School of Medicine, Washington, DC, United States.
Tong LiDepartment of Microbiology and Immunology. Georgetown University School of Medicine, Washington, DC, United States.
Jinya ChenDepartment of Microbiology and Immunology. Georgetown University School of Medicine, Washington, DC, United States.
Jai KumarDivision of Infectious Diseases and Tropical Medicine, Georgetown University School of Medicine, Washington, DC, United States.
Princy KumarDivision of Infectious Diseases and Tropical Medicine, Georgetown University School of Medicine, Washington, DC, United States.
Jing QinBiostatistics Research Branch, Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States.
Colleen HadiganLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Irini SeretiLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Jason V BakerHennepin Healthcare Research Institute, University of Minnesota, Minneapolis, MN, United States.
Marta CatalfamoDepartment of Microbiology and Immunology. Georgetown University School of Medicine, Washington, DC, United States.
Georgetown University · USNational Institute of Allergy and Infectious Diseases · USHennepin Healthcare Research Institute · USNational Institutes of Health · US

Funding

SWG 2: Cure Research Scientific Working GroupP30AI117970 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Italo Mocchetti · 2015 to 2026
$29.6M
Immunopathogenic Mechanisms of Human Immunodeficiency Virus (HIV) DiseaseZIAAI001121 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SERETI, IRINI · 2010 to 2025
$27.2M
The impact of HIV driven T cell immune activation in angiogenic CD8 T cell function: the role of PAR1 signalingR01AI145549 · NIAID · GEORGETOWN UNIVERSITY · PI CATALFAMO, MARTA L. · 2019 to 2024
$1.9M
NCI NIH HHS HHSN261200800001ENIAID NIH HHS P30 AI117970NIAID NIH HHS R01 AI145549
6 · The paper itself

Abstract

Endothelial inflammation and damage are the main drivers of cardiovascular risk/disease. Endothelial repair is mediated in part by recruitment of bone marrow endothelial progenitor/endothelial colony forming cells (EPC/ECFC). People with HIV (PWH) have increased cardiovascular risk and the impact of infection in endothelial repair is not well defined. The low frequencies and challenges to

Indexed as

AgedBiomarkersCD4-CD8 RatioChronic DiseaseEndothelial Progenitor CellsFemaleHIV InfectionsHumansImmunophenotypingInflammation MediatorsLipid MetabolismLipidsLymphocyte ActivationLymphocyte CountMaleMiddle AgedBiomarkersInflammation MediatorsLipidsendothelial inflammationendothelial progenitor cellsendothelial repairHIV infectionT cell activation

Identifiers

PMID34079548
PMCPMC8165313
OpenAlexW3161420830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.