Evidence map›Paper›PMID 34079438›Full record

ArticleFrontiers in molecular neuroscience2021

Single-Nucleus Chromatin Accessibility Landscape Reveals Diversity in Regulatory Regions Across Distinct Adult Rat Cortex.

Yeya Yu, Xiaoyu Wei, Qiuting Deng, Qing Lan, Yiping Guo, Lei Han, Yue Yuan, Peng Fan, Peiying Wu, Shuncheng Shangguan and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Genomic and Cis-Regulatory Basis of a Plastic CAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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  4. Combining Machine Learning and Multiplexed,bioRxiv : the preprint server for biology · 2025
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  12. A scATAC-seq atlas of stasis zone in rat skin burn injury wound process.Frontiers in cell and developmental biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Yeya YuBGI College, Zhengzhou University, Zhengzhou, China.
Xiaoyu WeiBGI-Shenzhen, Shenzhen, China.
Qiuting DengBGI-Shenzhen, Shenzhen, China.
Qing LanBGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
Yiping GuoCAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Lei HanBGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
Yue YuanBGI-Shenzhen, Shenzhen, China.
Peng FanCollege of Veterinary Medicine, Jilin University, Changchun, China.
Peiying WuBGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
Shuncheng ShangguanJoint School of Life Sciences, Guangzhou Medical University and Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Yang LiuBGI-Shenzhen, Shenzhen, China.
Yiwei LaiLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Giacomo VolpeLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Miguel A EstebanCollege of Veterinary Medicine, Jilin University, Changchun, China.
Chuanyu LiuBGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
Yong HouBGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
Longqi LiuBGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
University of Chinese Academy of Sciences · CNBGI Group (China) · CNChinese Academy of Sciences · CNGuangzhou Institutes of Biomedicine and Health · CNJilin University · CNShenzhen Bay Laboratory · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rats have been widely used as an experimental organism in psychological, pharmacological, and behavioral studies by modeling human diseases such as neurological disorders. It is critical to identify and characterize cell fate determinants and their regulatory mechanisms in single-cell resolutions across rat brain regions. Here, we applied droplet-based single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) to systematically profile the single-cell chromatin accessibility across four dissected brain areas in adult

Indexed as

chromatin accessibilityrat cerebral cortexregulatory elementsnATAC-seqtranscription factor

Identifiers

PMID34079438
PMCPMC8166204
OpenAlexW3161620422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.