ArticleFrontiers in neuroscience2021
Photoacoustic Mouse Brain Imaging Using an Optical Fabry-Pérot Interferometric Ultrasound Sensor.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Multiple reflection: A Route to enhanced sensitivity in beam-deflection optical ultrasound sensing.Photoacoustics · 2026Article
- Cross-regional real-time visualization of systemic physiology and dynamics with 3D panoramic photoacoustic computed tomography (3D-PanoPACT).Nature communications · 2025Article
- Principles of Doppler ultrasound and emerging blood flow imaging.Ultrasonography (Seoul, Korea) · 2025Article
- Deep tissue photoacoustic imaging with light and sound.Npj imaging · 2024Review
- Visualization of Microcirculation at Acupoints in vivo of Alzheimer's Disease Animal Model with Photoacoustic Microscope: A Pilot Study.Journal of Alzheimer's disease reports · 2024Article
- Parallel interrogation of the chalcogenide-based micro-ring sensor array for photoacoustic tomography.Nature communications · 2023Article
- A Comprehensive Review on Photoacoustic-Based Devices for Biomedical Applications.Sensors (Basel, Switzerland) · 2022Review
- High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator.BME frontiers · 2022Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photoacoustic (PA, or optoacoustic, OA) mesoscopy is a powerful tool for mouse cerebral imaging, which offers high resolution three-dimensional (3D) images with optical absorption contrast inside the optically turbid brain. The image quality of a PA mesoscope relies on the ultrasonic transducer which detects the PA signals. An all-optical ultrasound sensor based on a Fabry-Pérot (FP) polymer cavity has the following advantages: broadband frequency response, wide angular coverage and small footprint. Here, we present 3D PA mesoscope for mouse brain imaging using such an optical sensor. A heating laser was used to stabilize the sensor's cavity length during the imaging process. To acquire data for a 3D angiogram of the mouse brain, the sensor was mounted on a translation stage and raster scanned. 3D images of the mouse brain vasculature were reconstructed which showed cerebrovascular structure up to a depth of 8 mm with high quality. Imaging segmentation and dual wavelength imaging were performed to demonstrate the potential of the system in preclinical brain research.
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