ArticleOpen access rheumatology : research and reviews2021
Influence of Age and Sex on Disease Course and Treatment in Rheumatoid Arthritis.
Article in Open access rheumatology : research and reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- Effectiveness and cost-effectiveness of longstanding exercise therapy versus usual care in patients with axial spondyloarthritis or rheumatoid arthritis and severe limitations: The protocols of two parallel randomized controlled trials.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2022Trial
- Perspectives of patients with rheumatoid arthritis towards the use of parenteral methotrexate: a qualitative study.International journal of clinical pharmacy · 2026Article
- Endocrine enigmas: vascular health in females throughout the lifespan.American journal of physiology. Heart and circulatory physiology · 2025Review
- Ageism in Rheumatology: The Health Care Professional's Perspective.Arthritis care & research · 2025Article
- Fuzi alleviates cold-related rheumatoid arthritis via regulating gut microbiota and microbial bile acid metabolism.Chinese medicine · 2025Article
- Management of Late-Onset Rheumatoid Arthritis with Treat-to-Target Strategy.Drugs & aging · 2025Review
- "As long as you learn to adapt"-a longitudinal mixed-methods study exploring the first decade with rheumatoid arthritis.BMC rheumatology · 2025Article
- Association of ceramide risk scores with rheumatoid arthritis: a FINRISK population-based cohort study.BMJ open · 2025Article
- Exploring Anticitrullinated Antibodies (ACPAs) and Serum-Derived Exosomes Cargoes.Antibodies (Basel, Switzerland) · 2025Article
- A Cross-Sectional Study of Quality of Life, Treatment Adherence, and Health-Seeking Behavior in Turkish Patients with Rheumatoid Arthritis: Gender and Education as Key Predictors.Patient preference and adherence · 2025Article
- ElevatedJournal of inflammation research · 2025Article
- Micro-RNA content of circulating extracellular vesicles in early rheumatoid arthritis as biomarkers and mediators of methotrexate efficacy.Rheumatology (Oxford, England) · 2024Article
- Article
- Demographic, Clinical Profile of Rheumatoid Arthritis Patients and Their Association with Disease Severity in Ghana.International journal of rheumatology · 2024Article
- Tailoring Rheumatoid Arthritis Treatment through a Sex and Gender Lens.Journal of clinical medicine · 2023Review
- The Fidelity of Rheumatoid Arthritis Multivariate Diagnostic Biomarkers Using Discriminant Analysis and Binary Logistic Regression.Biomolecules · 2023Article
- Article
- Sex differences in long-term effects of collagen-induced arthritis in middle-aged mice.Frontiers in physiology · 2023Article
- A Population-Based Study Evaluating Retention in Rheumatology Care Among Patients With Rheumatoid Arthritis.ACR open rheumatology · 2022Article
- Autoimmune Idiopathic Inflammatory Myopathies: Pharmacological Differences and Similarities by Type of Myositis and by Sociodemographic Variables.International journal of rheumatology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMore than 50% of patients with rheumatoid arthritis (RA) are >65 years at diagnosis. Age of onset and sex may influence the disease course, outcome and treatment. This study follows a large cohort of patients with early RA to assess contributions of age and sex to disease outcomes.
methodsPatients from the BARFOT cohort, n=2837 (68% women), were followed for eight years at predefined time points to assess inflammation, function, joint destruction and treatment with disease modifying anti-rheumatic drugs (DMARDs) and glucocorticoids (GC). The patients were divided by sex and age at inclusion (<40, 40-54, 55-69 and ≥70 years).
resultsFor both sexes, disease activity, function and pain improved over time, significantly more in men than in women in all age groups. In men, those <40 years displayed significantly lower DAS28 compared with all other groups. This group was also the least represented group in the study. The Sharp van der Heijde Score (SHS) increased over time in both sexes and all age groups. Women ≥70 years showed less improvement in disability and the highest progression of SHS mainly due to increased joint space narrowing. Patients <40 years were more likely to receive biological DMARDs, while those ≥70 years more often received only GC treatment.
conclusionThere were significant age- and sex-dependent differences in the medical treatment and in outcome of RA 8 years after diagnosis. The differences were most pronounced in men<40 and women ≥70 years, but whether they are due to disease phenotype or treatment is unclear.
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