Evidence map›Paper›PMID 34079248›Full record

ArticleInternational journal of nanomedicine2021

The Influence of Silver Nanoparticles Against Toxic Effects of

Jaqueline de Cássia Proença-Assunção, Anna Paula Farias-de-França, Natalia Tribuiani, Jose Carlos Cogo, Rita de Cássia Collaço, Priscila Randazzo-Moura, Sílvio Roberto Consonni, Marco Vinicius Chaud, Carolina Alves Dos Santos, Yoko Oshima-Franco

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Inhibition of theFrontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jaqueline de Cássia Proença-AssunçãoPost-Graduate Program in Pharmaceutical Sciences, University of Sorocaba (Uniso), Sorocaba, SP, Brazil.
Anna Paula Farias-de-FrançaPharmacy Graduate Course, University of Sorocaba (Uniso), Sorocaba, SP, Brazil.
Natalia TribuianiPost-Graduate Program in Pharmaceutical Sciences, University of Sorocaba (Uniso), Sorocaba, SP, Brazil.
Jose Carlos CogoBioengineering and Biomedical Engineering Programs, Technological and Scientific Institute, Brazil University, São Paulo, Brazil.
Rita de Cássia CollaçoDepartment of Pharmacology, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, SP, Brazil.
Priscila Randazzo-MouraDepartment of Surgery, Pontifícia Universidade Católica De São Paulo (PUCSP), Sorocaba, SP, Brazil.
Sílvio Roberto ConsonniDepartment of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas, Campinas, SP, Brazil.ORCID 0000-0003-3149-021X
Marco Vinicius ChaudPost-Graduate Program in Pharmaceutical Sciences, University of Sorocaba (Uniso), Sorocaba, SP, Brazil.ORCID 0000-0003-3618-8415
Carolina Alves Dos SantosPharmacy Graduate Course, University of Sorocaba (Uniso), Sorocaba, SP, Brazil.
Yoko Oshima-FrancoPost-Graduate Program in Pharmaceutical Sciences, University of Sorocaba (Uniso), Sorocaba, SP, Brazil.ORCID 0000-0002-4972-8444
Universidade de Sorocaba · BRUniversidade Estadual de Campinas (UNICAMP) · BRPontifícia Universidade Católica de São Paulo · BRUniversidade Brasil · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA silver nanoparticle obtained by reducing salts with solid dispersion of curcumin (130 nm, 0.081 mg mL

methodsThe edematogenic effect was evaluated by plasma extravasation in rat dorsal skin after injection of 50 µg per site of venom alone or preincubated with 1, 10, and 100 µL of AgNPs; the myotoxicity was evaluated by measuring the creatine kinase released into the organ-bath before the treatment and at the end of each experiment; and neurotoxicity was evaluated in chick biventer cervicis using the conventional myographic technique, face to the exogenous acetylcholine (ACh) and potassium chloride (KCl) added into the bath before the treatment and after each experiment. Preliminarily, a concentration-response curve of AgNPs was carried out to select the concentration to be used for neutralizing assays, which consists of neutralizing the venom-induced neuromuscular paralysis and edema by preincubating AgNPs with venom for 30 min.

resultsThe

conclusionAgNPs interact with constituents of

Indexed as

ColubridaeMetal NanoparticlesAnimalsChickensCreatine KinaseCurcuminDose-Response Relationship, DrugEdemaMaleMuscle ContractionMuscle, SkeletalNeurotoxinsPhrenic NerveRatsSilverSnake VenomsCreatine KinaseCurcuminNeurotoxinsSilverSnake Venomschick biventer cervicisneuromuscular blockadeopisthoglyphous snakesPhilodryas olfersiisilver nanoparticles

Identifiers

PMID34079248
PMCPMC8164871
OpenAlexW3164203453

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.