ArticleClinical ophthalmology (Auckland, N.Z.)2021
Success of Primary Trabeculectomy in Advanced Open Angle Glaucoma.
Article in Clinical ophthalmology (Auckland, N.Z.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07152132 (Slow Coagulation Trans-Scleral Cyclophotocoagulation Versus Trabeculectomy in Medically Uncontrolled Open-Angle Glaucoma in Pseudophakic Patients), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Slow Coagulation Trans-Scleral Cyclophotocoagulation Versus Trabeculectomy in Medically Uncontrolled Open-Angle Glaucoma in Pseudophakic Patients
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Efficacy and safety of intraoperative injection of mitomycin C during trabeculectomy: a systematic review and meta-analysis.International ophthalmology · 2024Pooled it
- Comparison of surgical outcomes of suture gonioscopy-assisted transluminal trabeculotomy versus excisional goniotomy with Kahook dual blade at 12 months.Indian journal of ophthalmology · 2026Article
- Polypharmacy in glaucoma management: a narrative review.Irish journal of medical science · 2026Review
- Long-Term Intraocular Pressure-Lowering and Antifibrotic Effects of a Biodegradable HA-Mg Glaucoma Drainage Implant in a Chronic Glaucoma Rabbit Model.Translational vision science & technology · 2026Article
- Multicenter evaluation of machine and deep learning methods to predict glaucoma surgical outcomes.Frontiers in artificial intelligence · 2025Article
- One-Year Comparison of Efficacy and Safety of PreserFlo MicroShunt with Mitomycin C Applied by Sub-Tenon Injection Versus Sponge.Ophthalmology and therapy · 2025Article
- Long-Term Surgical Outcome of Trabeculectomy with Mitomycin C: A Comparison Between Primary and Secondary Glaucoma in Thailand.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Flow-Adjusted Trabeculectomy.Journal of clinical medicine · 2024Article
- Article
- Long-Term Efficacy of Successful Excisional Goniotomy with the Kahook Dual Blade.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Non-penetrating deep sclerectomy versus combined trabeculotomy-trabeculectomy in primary congenital glaucoma.Medical hypothesis, discovery & innovation ophthalmology journal · 2023Article
- XEN Gel Stent Implantation in Eyes With Previous Glaucoma Filtering Surgeries: A Case Series.Cureus · 2022Article
- Updates on the Diagnosis and Management of Glaucoma.Mayo Clinic proceedings. Innovations, quality & outcomes · 2022Review
- Predicting a reduction in intraocular pressure in glaucoma patients in the early period after a trabeculectomy: Development and assessment of a new predictive nomogram.Frontiers in ophthalmology · 2022Article
- Young glaucoma specialist practice patterns: Why do you do what you do?Advances in ophthalmology practice and researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe study assesed trabeculectomy survival in advanced open angle glaucoma (OAG).
methodsThis is a retrospective longitudinal study in advanced OAG undergoing primary trabeculectomy. Clinical and demographic parameters were recorded. Surgical survival (qualified/complete) was calculated by Kaplan-Meier analysis for multiple upper limits of intraocular pressure (IOP) with/without medication (≤21 mmHg, ≤18 mmHg, ≤15 mmHg, ≤12 mmHg); Cox hazard ratio analysis identified parameters influencing survival.
resultsWe included 165 eyes from 165 OAG patients: primary forms (POAG) - 86 eyes and secondary (pseudoexfoliative, SOAG) - 79 eyes; mean follow-up interval was 36.21 ± 13.49 months. Clinical parameters were comparable between sub-groups at baseline, except a higher IOP in SOAG vs POAG (36.6 ± 13.2 vs 32.7 ± 11.1 mmHg, p = 0.04); IOP reduction was similar (SOAG vs POAG) 53.93% vs 56.19%, p = 0.45, yet longer hospitalization (8.47 ± 4.39 (SOAG) vs 6.69 ± 3.01 days (POAG), p=0.03) and more medications (0.65 ± 0.24 vs 0.36 ± 0.16, p = 0.05) were needed to achieve comparable final IOP (16.0 ± 9.1 vs 15.1 ± 7.8 mmHg, p = 0.45). Kaplan Meier survival analysis applied for IOP ≤21 mmHg, ≤18 mmHg, ≤15 mmHg and ≤12 mmHg, revealed complete success in 26.2%, 27.3%, 34.5% and 54.6% eyes, respectively; qualified success was found in 45.7%, 48.6%, 77% and 88.6% eyes, respectively. Multiple medications at baseline diminished survival in all tested models (hazard ratio HR > 1, p<0.05), while 5FU+needling improved survival, mostly if combined with lower IOP regime: HR = 0.15, 95% CI = [0.07 -1.12], p = 0.06, if IOP ≤15 mmHg and HR = 0.09, 95% CI = [0.02-1.25], p = 0.06, if IOP ≤12 mmHg.
conclusionTrabeculectomy in advanced OAG reached very good survival rates (77% and 88.6%) at 36 months postoperative, if IOP could be maintained ≤15 mmHg, respectively ≤12 mmHg with medication and additional needling+5FU maneuvers. Specific factors influencing survival were identified for each success definition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.