ArticleNature2021
Tracing oncogene-driven remodelling of the intestinal stem cell niche.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 109 citations in OpenAlex.
- Cell competition driven by secreted ligands: Modeling liver metastasis of colorectal cancer.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Current Status of Intestinal Stem Cell Research: Mechanisms, Intestinal Diseases, and Organoid Development.Cells · 2026Review
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- Clonal biases dictate availability of colonic cancer driver mutations for transformation.Nature communications · 2026Article
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- Critical role of cell competition in gliomagenesis.bioRxiv : the preprint server for biology · 2026Article
- Stem cell competition.Current topics in developmental biology · 2026Review
- Article
- RHOA at the intersection of inflammation-driven and sporadic colorectal cancer.Frontiers in immunology · 2026Review
- Epithelial WNT secretion drives niche escape of developing gastric cancer.Molecular cancer · 2025Article
- Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells.Nature biotechnology · 2025Article
- Defining the mucosal ecosystem: epithelial-mesenchymal interdependence in gastrointestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2025Review
- CRISPR-StAR enables high-resolution genetic screening in complex in vivo models.Nature biotechnology · 2025Article
- Recent progress in the identification and in vitro culture of skin organoids.Regenerative therapy · 2025Review
- Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer.Life science alliance · 2025Article
- Redefining familial adenomatous polyposis: competition, cooperation, and the path to monoclonality.Familial cancer · 2025Review
- Article
- Patient-derived mini-colons enable long-term modeling of tumor-microenvironment complexity.Nature biotechnology · 2025Article
- Neural cell competition sculpting brain from cradle to grave.National science review · 2025Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 4 countries.
Min Kyu Yum *Wellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
Seungmin Han *Wellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
Juergen FinkWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Szu-Hsien Sam WuInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0002-6377-608X
Catherine DabrowskaWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Teodora TrendafilovaWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Roxana MustataWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Lemonia ChatzeliWellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
Roberta AzzarelliWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8160-7538
Irina PshenichnayaWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Eunmin LeeDepartment of New Biology, DGIST, Daegu, Republic of Korea.
Frances EnglandWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0821-8015
Jong Kyoung KimDepartment of New Biology, DGIST, Daegu, Republic of Korea.ORCID http://orcid.org/0000-0002-0257-0547
Daniel E StangeDepartment of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0003-4246-2230
Anna PhilpottWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3789-2463
Joo-Hyeon LeeWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-7364-6422
Bon-Kyoung KooWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. bonkyoung.koo@imba.oeaw.ac.at.ORCID http://orcid.org/0000-0002-4134-8033
Benjamin D SimonsWellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK. bds10@cam.ac.uk.ORCID http://orcid.org/0000-0002-3875-7071
Wellcome/MRC Cambridge Stem Cell Institute · GBDaegu Gyeongbuk Institute of Science and Technology · KRInstitute of Molecular Biotechnology · ATUniversity Hospital Carl Gustav Carus · DE
Funding
Cancer Research UK 23363Cancer Research UK 25636Medical Research Council MC_PC_17230Wellcome TrustWellcome Trust 092096Wellcome Trust 098357/Z/12/ZWellcome Trust 107633/Z/15/ZWellcome Trust 219478/Z/19/Z
Abstract
Interactions between tumour cells and the surrounding microenvironment contribute to tumour progression, metastasis and recurrence
Indexed as
OncogenesStem Cell NicheAnimalsClone CellsColorectal NeoplasmsFemaleIntestine, SmallMaleMiceMutationNeoplastic Stem CellsPhosphatidylinositol 3-KinasesReproducibility of ResultsSingle-Cell AnalysisTumor MicroenvironmentWnt ProteinsPhosphatidylinositol 3-KinasesWnt Proteins
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.