ArticleNature2021
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 1 pooled it
16.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
148 citing papers in PubMed, 1 synthesis or guideline pooled it, 243 citations in OpenAlex.
- Prognosis of recurrence after complete resection in early-stage lung adenocarcinoma based on molecular alterations: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
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- Resolving cell-cell interaction networks and their molecular logic in complex tissues.Nature methods · 2026Article
- Heterogeneity in cancer: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Cell competition driven by secreted ligands: Modeling liver metastasis of colorectal cancer.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Pathophysiology of colitis-associated colorectal cancer.Nature reviews. Gastroenterology & hepatology · 2026Review
- Age-related decline in niche self-renewal factors drives testis aging via Hairless, Imp, and Chinmo.Science advances · 2026Article
- Identification and prognostic analysis of genes related to CTNNB1 mutations in hepatocellular carcinoma.Biology direct · 2026Article
- POTEF upregulation drives hepatocellular carcinoma progression via oncogenic signaling and immune modulation.Scientific reports · 2026Article
- Loss of proton-sensing TDAG8 increases tumor progression in mouse models of colon cancer.Molecular oncology · 2026Article
- Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit.Immunity · 2026Article
- Beyond the chaos: How architecture structures tumour biology.The FEBS journal · 2026Review
- Article
- LDAcoop: Integrating non-linear population dynamics into the analysis of clonogenic growth in vitro.Molecular oncology · 2026Article
- Asymmetric division sustains stem cell heterogeneity in the Drosophila testicular niche.Communications biology · 2026Article
- Attenuation of the CpG island methylator phenotype and lack of WNT signalling activation restrains Kras mutant intestinal neoplasia.British journal of cancer · 2026Article
- Review
- Tumour promotion through the lens of evolution.Nature · 2026Review
- Colitis-Associated Carcinoma: The Quintessential Epithelial Neoplasia Driven by Chronic Inflammation.Cells · 2026Review
- Article
88 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
36 authors at 12 institutions in 6 countries.
Dustin J FlanaganCancer Research UK Beatson Institute, Glasgow, UK.
Nalle PentinmikkoInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-3578-1073
Kalle LuopajärviInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Nicky J WillisAlzheimer's Research UK UCL Drug Discovery Institute, University College London, London, UK.ORCID http://orcid.org/0000-0003-3245-5280
Kathryn GilroyCancer Research UK Beatson Institute, Glasgow, UK.
Alexander P RavenCancer Research UK Beatson Institute, Glasgow, UK.
Lynn McgarryCancer Research UK Beatson Institute, Glasgow, UK.ORCID http://orcid.org/0000-0002-7055-2615
Johanna I EnglundInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-9637-6843
Anna T WebbDepartment of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden.
Sandra ScharawDepartment of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-9428-3213
Nadia NasreddinIntestinal Stem Cell Biology Lab, Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3025-6213
Michael C HodderCancer Research UK Beatson Institute, Glasgow, UK.
Rachel A RidgwayCancer Research UK Beatson Institute, Glasgow, UK.ORCID http://orcid.org/0000-0003-0198-8244
Emma MinneeCancer Research UK Beatson Institute, Glasgow, UK.
Nathalie SphyrisCancer Research UK Beatson Institute, Glasgow, UK.
Ella GilchristCancer Research UK Beatson Institute, Glasgow, UK.ORCID http://orcid.org/0000-0003-3972-4121
Arafath K NajumudeenCancer Research UK Beatson Institute, Glasgow, UK.ORCID http://orcid.org/0000-0002-3764-5721
Beatrice RomagnoloUniversité de Paris, Institut Cochin, INSERM, CNRS, Paris, France.
Christine PerretUniversité de Paris, Institut Cochin, INSERM, CNRS, Paris, France.ORCID http://orcid.org/0000-0003-4710-7051
Ann C WilliamsColorectal Tumour Biology Group, School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-6009-7137
Hans CleversSpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3077-5582
Pirjo NummelaDepartment of Pathology, Applied Tumor Genomics, Research Programs Unit and HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0002-2768-8816
Marianne LähdeTranslational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Kari AlitaloTranslational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-7331-0902
Ville HietakangasInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Ann HedleyCancer Research UK Beatson Institute, Glasgow, UK.
William ClarkCancer Research UK Beatson Institute, Glasgow, UK.
Colin NixonCancer Research UK Beatson Institute, Glasgow, UK.ORCID http://orcid.org/0000-0002-8085-2160
Kristina KirschnerInstitute of Cancer Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0001-7607-8670
E Yvonne JonesDivision of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3834-1893
Ari RistimäkiDepartment of Pathology, Applied Tumor Genomics, Research Programs Unit and HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Simon J LeedhamIntestinal Stem Cell Biology Lab, Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK.
Paul V FishAlzheimer's Research UK UCL Drug Discovery Institute, University College London, London, UK.
Jean-Paul VincentThe Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-2305-5744
Pekka KatajistoInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. pekka.katajisto@helsinki.fi.ORCID http://orcid.org/0000-0002-3033-4189
Owen J SansomCancer Research UK Beatson Institute, Glasgow, UK. o.sansom@beatson.gla.ac.uk.ORCID http://orcid.org/0000-0001-9540-3010
Cancer Research UK Scotland Institute · GBUniversity of Helsinki · FICentre for Human Genetics · GBCentre National de la Recherche Scientifique · FRHarvard University · USKarolinska Institutet · SEThe Francis Crick Institute · GBAlzheimer’s Research UK · GBNew England Biolabs (United States) · USRoyal Netherlands Academy of Arts and Sciences · NLUniversity of Bristol · GBUniversity of Glasgow · GB
Funding
Cancer Research UK 17721Cancer Research UK 21139Cancer Research UK 27144Medical Research Council FC001204Medical Research Council MR/R017247/1Wellcome Trust 206314/Z/17/ZWellcome Trust 206341/Z/17/ZWellcome Trust FC001002
Abstract
The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT signalling
Indexed as
Cell CompetitionCell Transformation, NeoplasticGenes, APCMutationAdenomaAdenomatous Polyposis Coli ProteinAnimalsCell DifferentiationCell ProliferationColorectal NeoplasmsCulture Media, ConditionedDisease ProgressionEsterasesFemaleHumansLigandsAdenomatous Polyposis Coli Proteinadenomatous polyposis coli protein, mouseCulture Media, ConditionedEsterasesLigandsNotum protein, humanNotum protein, mouseWnt Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.