Evidence map›Paper›PMID 34079065›Full record

ArticleCommunications biology2021

PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation.

Yu-Ting Yen, May Chien, Pei-Yi Wu, Shih-Chieh Hung

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  4. Identification and validation ofBiomolecules & biomedicine · 2025
    Article
  5. Cellular crosstalk in the bone marrow niche.Journal of translational medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yu-Ting Yen *Drug Development Center, Institute of New Drug Development, China Medical University, Taichung, Taiwan.
May Chien *Drug Development Center, Institute of New Drug Development, China Medical University, Taichung, Taiwan.
Pei-Yi WuDrug Development Center, Institute of New Drug Development, China Medical University, Taichung, Taiwan.
Shih-Chieh HungDrug Development Center, Institute of New Drug Development, China Medical University, Taichung, Taiwan. hung3340@gmail.com.ORCID 0000-0003-1813-4616
China Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has not been well studied which cells and related mechanisms contribute to endochondral ossification. Here, we fate mapped the leptin receptor-expressing (LepR

Indexed as

AdipogenesisAnimalsBone and BonesBone DensityBromodomain Containing ProteinsCell DifferentiationCell ProliferationChondrogenesisCore Binding Factor Alpha 1 SubunitFemaleMaleMesenchymal Stem CellsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicBrd4 protein, mouseBromodomain Containing ProteinsCore Binding Factor Alpha 1 Subunitleptin receptor, mouseNuclear ProteinsProtein Phosphatase 2Receptors, LeptinRunx2 protein, mouseTranscription Factors

Identifiers

PMID34079065
PMCPMC8172534
OpenAlexW3164003157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.