Evidence map›Paper›PMID 34079054›Full record

ArticleCommunications biology2021

Control of impulsivity by G

Bastiaan van der Veen, Sampath K T Kapanaiah, Kasyoka Kilonzo, Peter Steele-Perkins, Martin M Jendryka, Stefanie Schulz, Bosiljka Tasic, Zizhen Yao, Hongkui Zeng, Thomas Akam and 5 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

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  15. The effects of early life stress on impulsivity.Neuroscience and biobehavioral reviews · 2022
    Review
  16. Article
  17. Article
  18. Animal Models of ADHD?Current topics in behavioral neurosciences · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Bastiaan van der VeenInstitute of Applied Physiology, Ulm University, Ulm, Germany.
Sampath K T KapanaiahInstitute of Applied Physiology, Ulm University, Ulm, Germany.
Kasyoka KilonzoInstitute of Applied Physiology, Ulm University, Ulm, Germany.
Peter Steele-PerkinsInstitute of Applied Physiology, Ulm University, Ulm, Germany.
Martin M JendrykaInstitute of Applied Physiology, Ulm University, Ulm, Germany.
Stefanie SchulzInstitute of Applied Physiology, Ulm University, Ulm, Germany.
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6861-4506
Zizhen YaoAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-9361-5607
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-0326-5878
Thomas AkamDepartment of Experimental Psychology, University of Oxford, Oxford, UK.
Janet R NicholsonBoehringer Ingelheim Pharma GmbH & Co. KG, Div. Research Germany, Biberach an der Riss, Germany.
Birgit LissInstitute of Applied Physiology, Ulm University, Ulm, Germany.ORCID 0000-0002-6733-9207
Wiebke NissenBoehringer Ingelheim Pharma GmbH & Co. KG, Div. Research Germany, Biberach an der Riss, Germany.
Anton PekcecBoehringer Ingelheim Pharma GmbH & Co. KG, Div. Research Germany, Biberach an der Riss, Germany.
Dennis KätzelInstitute of Applied Physiology, Ulm University, Ulm, Germany. dennis.kaetzel@uni-ulm.de.ORCID 0000-0002-7334-9823
Technische Hochschule Ulm · DEAllen Institute for Brain Science · USBoehringer Ingelheim (Germany) · DEUniversity of Oxford · GBUniversität Ulm · DE

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI NGAI, JOHN J. · 2017 to 2021
$64.7M
Establishing a Comprehensive and Standardized Cell Type Characterization PlatformU01MH105982 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, ZENG, HONGKUI · 2014 to 2016
$5.1M
NIMH NIH HHS U01 MH105982NIMH NIH HHS U19 MH114830
6 · The paper itself

Abstract

Pathological impulsivity is a debilitating symptom of multiple psychiatric diseases with few effective treatment options. To identify druggable receptors with anti-impulsive action we developed a systematic target discovery approach combining behavioural chemogenetics and gene expression analysis. Spatially restricted inhibition of three subdivisions of the prefrontal cortex of mice revealed that the anterior cingulate cortex (ACC) regulates premature responding, a form of motor impulsivity. Probing three G-protein cascades with designer receptors, we found that the activation of G

Indexed as

AnimalsClozapineFemaleGene ExpressionGTP-Binding Protein alpha Subunits, Gi-GoGyrus CinguliHumansImpulsive BehaviorMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPyramidal CellsReceptors, Metabotropic GlutamateSignal TransductionClozapineclozapine N-oxideGTP-Binding Protein alpha Subunits, Gi-GoReceptors, Metabotropic Glutamate

Identifiers

PMID34079054
PMCPMC8172539
OpenAlexW3164432555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.