Evidence map›Paper›PMID 34079049›Full record

ArticleNPJ digital medicine2021

Engineering digital biomarkers of interstitial glucose from noninvasive smartwatches.

Brinnae Bent, Peter J Cho, Maria Henriquez, April Wittmann, Connie Thacker, Mark Feinglos, Matthew J Crowley, Jessilyn P Dunn

Abstract read
In one paragraph

Article in NPJ digital medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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  12. Artificial Intelligence in Diabetes Care: Applications, Challenges, and Opportunities Ahead.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brinnae BentDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-7039-0177
Peter J ChoDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Maria HenriquezDepartment of Statistical Science, Duke University, Durham, NC, USA.
April WittmannDivision of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Connie ThackerDivision of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Mark FeinglosDivision of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Matthew J CrowleyDivision of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Jessilyn P DunnDepartment of Biomedical Engineering, Duke University, Durham, NC, USA. jessilyn.dunn@duke.edu.ORCID http://orcid.org/0000-0002-3241-8183

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prediabetes affects one in three people and has a 10% annual conversion rate to type 2 diabetes without lifestyle or medical interventions. Management of glycemic health is essential to prevent progression to type 2 diabetes. However, there is currently no commercially-available and noninvasive method for monitoring glycemic health to aid in self-management of prediabetes. There is a critical need for innovative, practical strategies to improve monitoring and management of glycemic health. In this study, using a dataset of 25,000 simultaneous interstitial glucose and noninvasive wearable smartwatch measurements, we demonstrated the feasibility of using noninvasive and widely accessible methods, including smartwatches and food logs recorded over 10 days, to continuously detect personalized glucose deviations and to predict the exact interstitial glucose value in real time with up to 84% and 87% accuracy, respectively. We also establish methods for designing variables using data-driven and domain-driven methods from noninvasive wearables toward interstitial glucose prediction.

Identifiers

PMID34079049
PMCPMC8172541

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.