Evidence map›Paper›PMID 34078999›Full record

ArticleScientific reports2021

Psychosocial stress and cortisol stress reactivity predict breast milk composition.

Anna Ziomkiewicz, Magdalena Babiszewska, Anna Apanasewicz, Magdalena Piosek, Patrycja Wychowaniec, Agnieszka Cierniak, Olga Barbarska, Marek Szołtysik, Dariusz Danel, Szymon Wichary

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06240676 (Examining the Effect of Breastfeeding Education Given to Mothers Based on Postpartum Awareness Practices on Breast Milk and Cortisol Hormone at the Newborn Circadian Level), which is not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06240676 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Examining the Effect of Breastfeeding Education Given to Mothers Based on Postpartum Awareness Practices on Breast Milk and Cortisol Hormone at the Newborn Circadian Level

TypeinterventionalSponsorKafkas UniversityRan2024 to 2024Enrolled54ConditionsMother Fetus Relations, Health BehaviorArmsAWARENESS-BASED COGNITIVE THERAPY
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Videoconferencing with the Hospitalized Premature Infant while Expressing Milk: A Randomized Crossover Trial.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2026
    Trial
  4. Trial
  5. Trial
  6. Review
  7. Psychological Stress Increases the Expression of Milk-Derived miR-210-5p.Journal of mammary gland biology and neoplasia · 2026
    Article
  8. Review
  9. Review
  10. Non-invasive physiological indicators of welfare in dairy cows.Animal welfare (South Mimms, England) · 2026
    Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Review
  16. Foods (Basel, Switzerland) · 2025
    Review
  17. Review
  18. Association Between Breastfeeding Intensity and Mammary Gland Involution Markers in Early Postpartum Among Women from Low-Income Households.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2025
    Article
  19. Returning to the Operating Room.Seminars in colon & rectal surgery · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Anna ZiomkiewiczInstitute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387, Kraków, Poland. anna.ziomkiewicz-wichary@uj.edu.pl.
Magdalena BabiszewskaLudwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.
Anna ApanasewiczLudwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.
Magdalena PiosekInstitute of Psychology, University of Wroclaw, J.W. Dawida 1, 50-527, Wroclaw, Poland.
Patrycja WychowaniecFaculty of Biology, Department of Human Biology, University of Wroclaw, Szewska 48, 50-139, Wroclaw, Poland.
Agnieszka CierniakFaculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Gustawa Herlinga-Grudzinskiego 1, 30-705, Krakow, Poland.
Olga BarbarskaLaboratory of Human Milk and Lactation Research At Regional Human Milk Bank in Holy Family Hospital, Faculty of Health Sciences, Medical University of Warsaw, Zwirki i Wigury 63a, 02-091, Warsaw, Poland.
Marek SzołtysikFaculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, J. Chelmonskiego 37, 51-630, Wrocław, Poland.
Dariusz DanelLudwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.
Szymon WicharyInstitute of Psychology, Jagiellonian University, Ingardena 6, 30-060, Krakow, Poland.
Institute of Psychology · PLLudwik Hirszfeld Institute of Immunology and Experimental Therapy · PLAndrzej Frycz Modrzewski Krakow University · PLJagiellonian University · PLMedical University of Warsaw · PLPolish Academy of Sciences · PLUniversity of Wrocław · PLWroclaw University of Environmental and Life Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied a sample of 146 Polish, exclusively breastfeeding mothers and their healthy born on time infants to explore the effect of perinatal psychosocial stress on breast milk composition. Maternal perinatal stress was assessed using Recent Life Changes Questionnaire summarizing stressful events from the previous six months. Stress reactivity was determined by administering the cold pressor test and measuring cortisol in saliva samples taken during the test. Breast milk sample was taken to measure energy, protein, fat, lactose, and fatty acid content. Analyses revealed that stress reactivity was positively associated with milk fat and long-chain unsaturated fatty acids and negatively associated with milk lactose. Perinatal psychosocial stress negatively affected energy density, fat as well as medium-chain and long-chain saturated fatty acids in milk. These results, together with previous studies, advocate monitoring maternal psychological status during the peripartum to promote breastfeeding and healthy infant nutrition.

Indexed as

Stress, PsychologicalAdultFemaleHumansHydrocortisoneInfant, NewbornMilk, HumanPregnancySalivaHydrocortisone

Identifiers

PMID34078999
PMCPMC8172899
OpenAlexW3165298224

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.