Evidence map›Paper›PMID 34078903›Full record

ArticleNature communications2021

Dielectric nanohole array metasurface for high-resolution near-field sensing and imaging.

Donato Conteduca, Isabel Barth, Giampaolo Pitruzzello, Christopher P Reardon, Emiliano R Martins, Thomas F Krauss

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Donato ConteducaPhotonics Group, Department of Physics, University of York, York, UK. donato.conteduca@york.ac.uk.ORCID 0000-0003-0917-2709
Isabel BarthPhotonics Group, Department of Physics, University of York, York, UK.ORCID 0000-0003-3781-7228
Giampaolo PitruzzelloPhotonics Group, Department of Physics, University of York, York, UK.ORCID 0000-0002-8030-7699
Christopher P ReardonPhotonics Group, Department of Physics, University of York, York, UK.ORCID 0000-0002-7550-6415
Emiliano R MartinsSão Carlos School of Engineering, Department of Electrical and Computer Engineering, University of São Paulo, São Carlos-SP, Brazil.
Thomas F KraussPhotonics Group, Department of Physics, University of York, York, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dielectric metasurfaces support resonances that are widely explored both for far-field wavefront shaping and for near-field sensing and imaging. Their design explores the interplay between localised and extended resonances, with a typical trade-off between Q-factor and light localisation; high Q-factors are desirable for refractive index sensing while localisation is desirable for imaging resolution. Here, we show that a dielectric metasurface consisting of a nanohole array in amorphous silicon provides a favourable trade-off between these requirements. We have designed and realised the metasurface to support two optical modes both with sharp Fano resonances that exhibit relatively high Q-factors and strong spatial confinement, thereby concurrently optimizing the device for both imaging and biochemical sensing. For the sensing application, we demonstrate a limit of detection (LOD) as low as 1 pg/ml for Immunoglobulin G (IgG); for resonant imaging, we demonstrate a spatial resolution below 1 µm and clearly resolve individual E. coli bacteria. The combined low LOD and high spatial resolution opens new opportunities for extending cellular studies into the realm of microbiology, e.g. for studying antimicrobial susceptibility.

Indexed as

Biosensing TechniquesDielectric SpectroscopyEscherichia coliHumansImmunoglobulin GLimit of DetectionMolecular ImagingNanostructuresRefractometrySiliconSingle-Cell AnalysisSurface PropertiesImmunoglobulin GSilicon

Identifiers

PMID34078903
PMCPMC8172834

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.