ArticleNature communications2021
Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85 citing papers in PubMed, 152 citations in OpenAlex.
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- Shifts in leaf phosphorus fractions as dependent on plant age as an adaptive strategy for survival in the shade-tolerant Coptis chinensis.Annals of botany · 2026Article
- Genome-wide identification and characterization of methyltransferase involved in benzylisoquinoline alkaloids biosynthesis fromChinese herbal medicines · 2026Article
- A comprehensive assessment of climate and topographic changes to identify conservation gaps for the critically endangered speciesFrontiers in plant science · 2026Article
- Targeting the Gut Microbiota with Herbal Compounds from Traditional Chinese Medicine: A Mechanistic Synthesis of a Novel Therapeutic Approach for Ulcerative Colitis.Journal of inflammation research · 2026Review
- Genome-Wide Identification and Analysis of bZIP Transcription Factors inInternational journal of molecular sciences · 2025Article
- A high-quality chromosome-level reference genome of Pulsatilla chinensis.Scientific data · 2025Article
- Analysis of a near telomere-to-telomere genome of Phellodendron amurense reveals insights into berberine biosynthesis.Nature communications · 2025Article
- The whole-genome map of Astragalus mongholicus provides ideas for the synthesis of glutathione and flavonoid.BMC genomics · 2025Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
26 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chinese goldthread (Coptis chinensis Franch.), a member of the Ranunculales, represents an important early-diverging eudicot lineage with diverse medicinal applications. Here, we present a high-quality chromosome-scale genome assembly and annotation of C. chinensis. Phylogenetic and comparative genomic analyses reveal the phylogenetic placement of this species and identify a single round of ancient whole-genome duplication (WGD) shared by the Ranunculaceae. We characterize genes involved in the biosynthesis of protoberberine-type alkaloids in C. chinensis. In particular, local genomic tandem duplications contribute to member amplification of a Ranunculales clade-specific gene family of the cytochrome P450 (CYP) 719. The functional versatility of a key CYP719 gene that encodes the (S)-canadine synthase enzyme involved in the berberine biosynthesis pathway may play critical roles in the diversification of other berberine-related alkaloids in C. chinensis. Our study provides insights into the genomic landscape of early-diverging eudicots and provides a valuable model genome for genetic and applied studies of Ranunculales.
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